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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202207434
|2 doi
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|a pubmed24n1171.xml
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|a (NLM)36630969
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Chen, Kaikai
|e verfasserin
|4 aut
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| 245 |
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|a Super-Resolution Detection of DNA Nanostructures Using a Nanopore
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 24.03.2023
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|a Date Revised 24.03.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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|a High-resolution analysis of biomolecules has brought unprecedented insights into fundamental biological processes and dramatically advanced biosensing. Notwithstanding the ongoing resolution revolution in electron microscopy and optical imaging, only a few methods are presently available for high-resolution analysis of unlabeled single molecules in their native states. Here, label-free electrical sensing of structured single molecules with a spatial resolution down to single-digit nanometers is demonstrated. Using a narrow solid-state nanopore, the passage of a series of nanostructures attached to a freely translocating DNA molecule is detected, resolving individual nanostructures placed as close as 6 nm apart and with a surface-to-surface gap distance of only 2 nm. Such super-resolution ability is attributed to the nanostructure-induced enhancement of the electric field at the tip of the nanopore. This work demonstrates a general approach to improving the resolution of single-molecule nanopore sensing and presents a critical advance towards label-free, high-resolution DNA sequence mapping, and digital information storage independent of molecular motors
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|a Journal Article
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|a DNA nanostructures
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|a biosensing
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|a nanopores
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|a single molecules
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|a super-resolution
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|a DNA
|2 NLM
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|a 9007-49-2
|2 NLM
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| 700 |
1 |
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|a Choudhary, Adnan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sandler, Sarah E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maffeo, Christopher
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ducati, Caterina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Aksimentiev, Aleksei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Keyser, Ulrich F
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 12 vom: 01. März, Seite e2207434
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:35
|g year:2023
|g number:12
|g day:01
|g month:03
|g pages:e2207434
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|u http://dx.doi.org/10.1002/adma.202207434
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