Rapid Identification and Monitoring of Multiple Bacterial Infections Using Printed Nanoarrays

Rapid Identification and Monitoring of Multiple Bacterial Infections Using Printed Nanoarrays

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 12 vom: 01. März, Seite e2211363
1. Verfasser: Zhang, Zeying (VerfasserIn)
Weitere Verfasser: Sun, Yali, Yang, Yaqi, Yang, Xu, Wang, Huadong, Yun, Yang, Pan, Xiangyu, Lian, Zewei, Kuzmin, Artem, Ponkratova, Ekaterina, Mikhailova, Julia, Xie, Zian, Chen, Xiaoran, Pan, Qi, Chen, Bingda, Xie, Hongfei, Wu, Tingqing, Chen, Sisi, Chi, Jimei, Liu, Fangyi, Zuev, Dmitry, Su, Meng, Song, Yanlin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article bacterial diagnostics biosensors light scattering nanoarrays printing
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520 |a Fast and accurate detection of microbial cells in clinical samples is highly valuable but remains a challenge. Here, a simple, culture-free diagnostic system is developed for direct detection of pathogenic bacteria in water, urine, and serum samples using an optical colorimetric biosensor. It consists of printed nanoarrays chemically conjugated with specific antibodies that exhibits distinct color changes after capturing target pathogens. By utilizing the internal capillarity inside an evaporating droplet, target preconcentration is achieved within a few minutes to enable rapid identification and more efficient detection of bacterial pathogens. More importantly, the scattering signals of bacteria are significantly amplified by the nanoarrays due to strong near-field localization, which supports a visualizable analysis of the growth, reproduction, and cell activity of bacteria at the single-cell level. Finally, in addition to high selectivity, this nanoarray-based biosensor is also capable of accurate quantification and continuous monitoring of bacterial load on food over a broad linear range, with a detection limit of 10 CFU mL-1 . This work provides an accessible and user-friendly tool for point-of-care testing of pathogens in many clinical and environmental applications, and possibly enables a breakthrough in early prevention and treatment 
650 4 |a Journal Article 
650 4 |a bacterial diagnostics 
650 4 |a biosensors 
650 4 |a light scattering 
650 4 |a nanoarrays 
650 4 |a printing 
700 1 |a Sun, Yali  |e verfasserin  |4 aut 
700 1 |a Yang, Yaqi  |e verfasserin  |4 aut 
700 1 |a Yang, Xu  |e verfasserin  |4 aut 
700 1 |a Wang, Huadong  |e verfasserin  |4 aut 
700 1 |a Yun, Yang  |e verfasserin  |4 aut 
700 1 |a Pan, Xiangyu  |e verfasserin  |4 aut 
700 1 |a Lian, Zewei  |e verfasserin  |4 aut 
700 1 |a Kuzmin, Artem  |e verfasserin  |4 aut 
700 1 |a Ponkratova, Ekaterina  |e verfasserin  |4 aut 
700 1 |a Mikhailova, Julia  |e verfasserin  |4 aut 
700 1 |a Xie, Zian  |e verfasserin  |4 aut 
700 1 |a Chen, Xiaoran  |e verfasserin  |4 aut 
700 1 |a Pan, Qi  |e verfasserin  |4 aut 
700 1 |a Chen, Bingda  |e verfasserin  |4 aut 
700 1 |a Xie, Hongfei  |e verfasserin  |4 aut 
700 1 |a Wu, Tingqing  |e verfasserin  |4 aut 
700 1 |a Chen, Sisi  |e verfasserin  |4 aut 
700 1 |a Chi, Jimei  |e verfasserin  |4 aut 
700 1 |a Liu, Fangyi  |e verfasserin  |4 aut 
700 1 |a Zuev, Dmitry  |e verfasserin  |4 aut 
700 1 |a Su, Meng  |e verfasserin  |4 aut 
700 1 |a Song, Yanlin  |e verfasserin  |4 aut 
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