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NLM351216189 |
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cr uuu---uuuuu |
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231226s2023 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2022.109221
|2 doi
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|a pubmed25n1170.xml
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|a (DE-627)NLM351216189
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|a (NLM)36610524
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|a (PII)S1521-6616(22)00302-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Chen, Fei-Fei
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Renal NLRP3 Inflammasome activation is associated with disease activity in lupus nephritis
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.02.2023
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|a Date Revised 18.03.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
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|a The current study was initiated to comprehensively evaluate renal NLRP3 inflammasome pathway activation in lupus nephritis (LN) patients and their clinicopathological significances based on a Chinese LN cohort. We found that the expressions of NLRP3, ASC, caspase-1, IL-1β and IL-18 were all significantly higher in the kidneys of LN patients and were predominantly expressed in glomerular mesangial cells, podocytes, renal tubular epithelial cells and macrophages. The expressions of NLRP3, ASC, caspase-1 and IL-1β were positively correlated to SLEDAI scores and several renal pathological activity indices, while the expression of NLRP3 was negatively associated with chronicity scores. Moreover, the foot process width was positively correlated with glomerular caspase-1 levels, and several podocyte injury markers were decreased significantly in LN patients with higher caspase-1 expression compared with those with lower expression. Our findings indicated that renal NLRP3 inflammasome was activated in LN patients and correlated with disease activity, which needs further explorations
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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4 |
|a Disease activity
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|a Lupus nephritis
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|a NLRP3 inflammasome
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|a Podocyte injury.
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| 650 |
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|a Systemic lupus erythematosus
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| 650 |
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7 |
|a Inflammasomes
|2 NLM
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| 650 |
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|a NLR Family, Pyrin Domain-Containing 3 Protein
|2 NLM
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| 650 |
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|a Caspase 1
|2 NLM
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| 650 |
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7 |
|a EC 3.4.22.36
|2 NLM
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| 700 |
1 |
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|a Liu, Xiao-Tian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tao, Juan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mao, Zhao-Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tan, Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qu, Zhen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Feng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 247(2023) vom: 05. Feb., Seite 109221
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
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|g volume:247
|g year:2023
|g day:05
|g month:02
|g pages:109221
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|u http://dx.doi.org/10.1016/j.clim.2022.109221
|3 Volltext
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