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DE-627 |
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20231226050758.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2022.109214
|2 doi
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|a pubmed24n1170.xml
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|a (DE-627)NLM351198466
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|a (NLM)36608744
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|a (PII)S1521-6616(22)00295-9
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Roggenbuck, Dirk
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Human glycoprotein-2 expressed in Brunner glands - A putative autoimmune target and link between Crohn's and coeliac disease
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 14.02.2023
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|a Date Revised 18.03.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Glycoprotein 2 (GP2) is an autoantigen in Crohn's (CD) and coeliac disease (CeD). We assessed GP2-isoform (GP21-4)-expression in intestinal biopsies of paediatric patients with CD, CeD, ulcerative colitis (UC), and healthy children (HC). Transcription of GP21-4 was elevated in proximal small intestine in CeD and CD patients (only GP22/4) compared to jejunum (CeD/CD) and large bowel (CD). CeD patients demonstrated higher duodenal GP22/4-mRNA levels compared to HC/UC patients whereas CD patients showed higher GP24-mRNA levels compared to UC patients. Duodenal synthesis of only small GP2 isoforms (GP23/4) was demonstrated in epithelial cells in patients/HC and in Brunner glands (also large isoforms) with a more frequent apical location in CD/CeD patients. All four GP2 isoforms interacted with gliadin and phosphopeptidomannan. Gliadin digestion improved binding to GP2 isoforms. GP21-4 binding to CeD/CD-related antigens, elevated duodenal GP21-4-mRNA transcription, and GP2-protein secretion in Brunner glands of CeD/CD patients suggest an autoimmune CeD/CD link
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Celiac disease
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| 650 |
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4 |
|a Crohn's disease
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| 650 |
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4 |
|a Zymogen granule membrane glycoprotein GP2
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| 650 |
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|a Gliadin
|2 NLM
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| 650 |
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|a 9007-90-3
|2 NLM
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| 650 |
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|a GPI-Linked Proteins
|2 NLM
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| 650 |
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|a Autoantibodies
|2 NLM
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| 650 |
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|a Protein Isoforms
|2 NLM
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| 650 |
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|a RNA, Messenger
|2 NLM
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| 700 |
1 |
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|a Goihl, Alexander
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sowa, Mandy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lopens, Steffi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rödiger, Stefan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schierack, Peter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Conrad, Karsten
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sommer, Ulrich
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jöhrens, Korinna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Grützmann, Robert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Reinhold, Dirk
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Laass, Martin W
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 247(2023) vom: 15. Feb., Seite 109214
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:247
|g year:2023
|g day:15
|g month:02
|g pages:109214
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2022.109214
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 247
|j 2023
|b 15
|c 02
|h 109214
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