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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.chemmater.2c01746
|2 doi
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|a eng
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|a Aires, Antonio
|e verfasserin
|4 aut
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|a Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents
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|c 2022
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Revised 15.05.2023
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|a published: Print-Electronic
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|a CommentIn: Nat Rev Chem. 2023 Mar;7(3):142. - PMID 37117906
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|a Citation Status PubMed-not-MEDLINE
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|a © 2022 The Authors. Published by American Chemical Society.
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|a Iron oxide nanoparticles (IONPs) have become one of the most promising nanomaterials for biomedical applications because of their biocompatibility and physicochemical properties. This study demonstrates the use of protein engineering as a novel approach to design scaffolds for the tunable synthesis of ultrasmall IONPs. Rationally designed proteins, containing different number of metal-coordination sites, were evaluated to control the size and the physicochemical and magnetic properties of a set of protein-stabilized IONPs (Prot-IONPs). Prot-IONPs, synthesized through an optimized coprecipitation approach, presented good T1 and T2 relaxivity values, stability, and biocompatibility, showing potential for magnetic resonance imaging (MRI) applications
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|a Journal Article
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|a Fernández-Afonso, Yilian
|e verfasserin
|4 aut
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|a Guedes, Gabriela
|e verfasserin
|4 aut
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|a Guisasola, Eduardo
|e verfasserin
|4 aut
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|a Gutiérrez, Lucía
|e verfasserin
|4 aut
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|a Cortajarena, Aitziber L
|e verfasserin
|4 aut
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|i Enthalten in
|t Chemistry of materials : a publication of the American Chemical Society
|d 1998
|g 34(2022), 24 vom: 27. Dez., Seite 10832-10841
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|x 0897-4756
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|g volume:34
|g year:2022
|g number:24
|g day:27
|g month:12
|g pages:10832-10841
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|u http://dx.doi.org/10.1021/acs.chemmater.2c01746
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