Acid-Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer

Acid-Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 10 vom: 09. März, Seite e2209910
1. Verfasser: Chen, Fangmin (VerfasserIn)
Weitere Verfasser: Li, Tianliang, Zhang, Huijuan, Saeed, Madiha, Liu, Xiaoying, Huang, Lujia, Wang, Xiyuan, Gao, Jing, Hou, Bo, Lai, Yi, Ding, Chunyong, Xu, Zhiai, Xie, Zuoquan, Luo, Min, Yu, Haijun
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article STING cascade activation acid-ionizable nanoadjuvants cancer vaccines iron oxide nanoparticles personalized immunotherapy Cancer Vaccines Interferons 9008-11-1
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520 |a The critical challenge for cancer vaccine-induced T-cell immunity is the sustained activation of antigen cross-presentation in antigen-presenting cells (APCs) with innate immune stimulation. In this study, it is first discovered that the clinically used magnetic contrast agents, iron oxide nanoparticles (IONPs), markedly augment the type-I interferon (IFN-I) production profile of the stimulator of interferon genes (STING) agonist MSA-2 and achieve a 16-fold dosage-sparing effect in the human STING haplotype. Acid-ionizable copolymers are coassembled with IONPs and MSA-2 into iron nanoadjuvants to concentrate STING activation in the draining lymph nodes. The top candidate iron nanoadjuvant (PEIM) efficiently delivers the model antigen ovalbumin (OVA) to CD169+ APCs and facilitates antigen cross-presentation to elicit a 55-fold greater frequency of antigen-specific CD8+ cytotoxic T-lymphocyte response than soluble antigen. PEIMOVA nanovaccine immunization induces potent and durable antitumor immunity to prevent tumor lung metastasis and eliminate established tumors. Moreover, PEIM nanoadjuvant is applicable to deliver autologous tumor antigen and synergizes with immune checkpoint blockade therapy for prevention of postoperative tumor recurrence and distant metastasis in B16-OVA melanoma and MC38 colorectal tumor models. The acid-ionizable iron nanoadjuvant offers a generalizable and readily translatable strategy to augment STING cascade activation and antigen cross-presentation for personalized cancer vaccination immunotherapy 
650 4 |a Journal Article 
650 4 |a STING cascade activation 
650 4 |a acid-ionizable nanoadjuvants 
650 4 |a cancer vaccines 
650 4 |a iron oxide nanoparticles 
650 4 |a personalized immunotherapy 
650 7 |a Cancer Vaccines  |2 NLM 
650 7 |a Interferons  |2 NLM 
650 7 |a 9008-11-1  |2 NLM 
700 1 |a Li, Tianliang  |e verfasserin  |4 aut 
700 1 |a Zhang, Huijuan  |e verfasserin  |4 aut 
700 1 |a Saeed, Madiha  |e verfasserin  |4 aut 
700 1 |a Liu, Xiaoying  |e verfasserin  |4 aut 
700 1 |a Huang, Lujia  |e verfasserin  |4 aut 
700 1 |a Wang, Xiyuan  |e verfasserin  |4 aut 
700 1 |a Gao, Jing  |e verfasserin  |4 aut 
700 1 |a Hou, Bo  |e verfasserin  |4 aut 
700 1 |a Lai, Yi  |e verfasserin  |4 aut 
700 1 |a Ding, Chunyong  |e verfasserin  |4 aut 
700 1 |a Xu, Zhiai  |e verfasserin  |4 aut 
700 1 |a Xie, Zuoquan  |e verfasserin  |4 aut 
700 1 |a Luo, Min  |e verfasserin  |4 aut 
700 1 |a Yu, Haijun  |e verfasserin  |4 aut 
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773 1 8 |g volume:35  |g year:2023  |g number:10  |g day:09  |g month:03  |g pages:e2209910 
856 4 0 |u http://dx.doi.org/10.1002/adma.202209910  |3 Volltext 
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