Efficacy and safety of rituximab for primary nephrotic syndrome with acute kidney injury A two-center prospective cohort study

Efficacy and safety of rituximab for primary nephrotic syndrome with acute kidney injury : A two-center prospective cohort study

Copyright © 2022 Elsevier Inc. All rights reserved.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 246(2023) vom: 28. Jan., Seite 109211
Auteur principal: Xu, Yili (Auteur)
Autres auteurs: Huang, Yiqing, Zhang, Chengning, Sun, Lianqin, Sun, Zhuxing, Wang, Liang, Zhang, Bo, Yuan, Yanggang, Xing, Changying, Mao, Huijuan
Format: Article en ligne
Langue:English
Publié: 2023
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Acute kidney injury Nephrotic syndrome Prospective cohort Rituximab Targets driven 4F4X42SYQ6 Immunosuppressive Agents
Description
Résumé:Copyright © 2022 Elsevier Inc. All rights reserved.
The purpose of this study was to investigate the efficacy and safety of a low-dose Rituximab (RTX) regimen driven by peripheral blood B lymphocyte count in the treatment of adult patients with nephrotic syndrome (NS) complicated with acute kidney disease (AKI). We conducted a prospective single-arm study to evaluate the effect of B cells-driven RTX regimen. Patients with NS (MCD, FSGS, MN, IgAN) complicated with AKI fulfilling the inclusion criteria were eligible for this study. Patients were followed up at intervals of 2 months. Student's t-test and Chi-squared test were used to analyze normally distributed continuous variables and non-normally distributed continuous variables, respectively. From August 2018 to January 2022, 23 patients met the inclusion criteria and agreed to participate in the study. 3, 9, and 11 patients were AKI stage 1, 2, and 3, respectively. From baseline to the latest follow-up, 20 patients had complete and partial recovery of renal function. Accompanied by depletion of B cells, significant reduction of urinary protein excretion, serum total cholesterol, and the number of relapses were observed during the 12 months after the first RTX infusion as compared with during the 12 months before RTX injection. The number of patients who maintained steroids and immunosuppressive medications also remarkably decreased. This study indicates that the targets-driven treatment of low-dose RTX can achieve a high remission rate and alleviate the loss of kidney function in treating NS with AKI. The long-term efficacy, side effects, and therapeutic economics of RTX are reasonable
Description:Date Completed 17.01.2023
Date Revised 12.02.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2022.109211