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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c02408
|2 doi
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|a pubmed25n1168.xml
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|a (NLM)36562662
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a García, Lucia
|e verfasserin
|4 aut
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| 245 |
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|a Fe3O4-SiO2 Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.01.2023
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|a Date Revised 01.02.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Hybrid magnetic nanoparticles made up of an iron oxide, Fe3O4, core and a mesoporous SiO2 shell with high magnetization and a large surface area were proposed as an efficient drug delivery platform. The core/shell structure was synthesized by two seed-mediated growth steps combining solvothermal and sol-gel approaches and using organic molecules as a porous scaffolding template. The system presents a mean particle diameter of 30(5) nm (9 nm magnetic core diameter and 10 nm silica shell thickness) with superparamagnetic behavior, saturation magnetization of 32 emu/g, and a significant AC magnetic-field-induced heating response (SAR = 63 W/gFe3O4, measured at an amplitude of 400 Oe and a frequency of 307 kHz). Using ibuprofen as a model drug, the specific surface area (231 m2/g) of the porous structure exhibits a high molecule loading capacity (10 wt %), and controlled drug release efficiency (67%) can be achieved using the external AC magnetic field for short time periods (5 min), showing faster and higher drug desorption compared to that of similar stimulus-responsive iron oxide-based nanocarriers. In addition, it is demonstrated that the magnetic field-induced drug release shows higher efficiency compared to that of the sustained release at fixed temperatures (47 and 53% for 37 and 42 °C, respectively), considering that the maximum temperature reached during the exposure to the magnetic field is well below (31 °C). Therefore, it can be hypothesized that short periods of exposure to the oscillating field induce much greater heating within the nanoparticles than in the external solution
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a ferric oxide
|2 NLM
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|a 1K09F3G675
|2 NLM
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|a Drug Carriers
|2 NLM
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|a Delayed-Action Preparations
|2 NLM
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|a Silicon Dioxide
|2 NLM
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|a 7631-86-9
|2 NLM
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|a Ibuprofen
|2 NLM
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| 650 |
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|a WK2XYI10QM
|2 NLM
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| 700 |
1 |
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|a Garaio, Eneko
|e verfasserin
|4 aut
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1 |
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|a López-Ortega, Alberto
|e verfasserin
|4 aut
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1 |
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|a Galarreta-Rodriguez, Itziar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cervera-Gabalda, Laura
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cruz-Quesada, Guillermo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cornejo, Alfonso
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Garrido, Julián J
|e verfasserin
|4 aut
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1 |
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|a Gómez-Polo, Cristina
|e verfasserin
|4 aut
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|a Pérez-Landazábal, José Ignacio
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 39(2023), 1 vom: 10. Jan., Seite 211-219
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:39
|g year:2023
|g number:1
|g day:10
|g month:01
|g pages:211-219
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|u http://dx.doi.org/10.1021/acs.langmuir.2c02408
|3 Volltext
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|d 39
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|h 211-219
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