Functionalized biological metal-organic framework with nanosized coronal structure and hierarchical wrapping pattern for enhanced targeting therapy
© 2022 Elsevier B.V. All rights reserved.
| Publié dans: | Chemical engineering journal (Lausanne, Switzerland : 1996). - 1999. - 456(2023) vom: 15. Jan., Seite 140963 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2023
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| Accès à la collection: | Chemical engineering journal (Lausanne, Switzerland : 1996) |
| Sujets: | Journal Article Cancer therapy Coronal structure Drug delivery Metal-organic framework Precise targeting |
| Résumé: | © 2022 Elsevier B.V. All rights reserved. Inefficient tumor-targeted delivery and uncontrolled drug release are the major obstacles in cancer chemotherapy. Herein, inspired by the targeting advantage of coronavirus from its size and coronal structure, a coronal biological metal-organic framework nanovehicle (named as corona-BioMOF) is constructed for improving its precise cancer targeting ability. The designed corona-BioMOF is constructed as the carriers-encapsulated carrier model by inner coated with abundant protein-nanocaged doxorubicin particles and external decorated with high-affinity apoferritin proteins to form the spiky surface for constructing the specific coronal structure. The corona-BioMOF shows a higher affinity and an enhanced targeting ability towards receptor-positive cancer cells compared to that of MOF-drug composites without spiky surface. It also exhibits the hierarchical wrapping pattern-endowed controlled lysosome-specific drug release and remarkable tumor lethality in vivo. Moreover, water-induced surface defect-based protein handle mechanism is first proposed to shape the coronal-BioMOF. This work will provide a better inspiration for nanovehicle construction and be broadly useful for clinical precision nanomedicine |
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| Description: | Date Revised 12.09.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
| ISSN: | 1385-8947 |
| DOI: | 10.1016/j.cej.2022.140963 |