Synthesis and Self-Assembly of UV-Cross-Linkable Amphiphilic Polyoxazoline Block Copolymers Importance of Multitechnique Characterization

Synthesis and Self-Assembly of UV-Cross-Linkable Amphiphilic Polyoxazoline Block Copolymers : Importance of Multitechnique Characterization

In the nanomedicine field, there is a need to widen the availability of nanovectors to compensate for the increasingly reported side effects of poly(ethene glycol). Nanovectors enabling cross-linking can further optimize drug delivery. Cross-linkable polyoxazolines are therefore relevant candidates...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 38(2022), 51 vom: 27. Dez., Seite 16144-16155
1. Verfasser: Belkhir, Kedafi (VerfasserIn)
Weitere Verfasser: Cerlati, Orélia, Heaugwane, Diana, Tosi, Alice, Benkhaled, Belkacem Tarek, Brient, Pierre-Louis, Chatard, Camille, Graillot, Alain, Catrouillet, Sylvain, Balor, Stéphanie, Goudounèche, Dominique, Payré, Bruno, Laborie, Pascale, Lim, Jia-Hui, Putaux, Jean-Luc, Vicendo, Patricia, Gibot, Laure, Lonetti, Barbara, Mingotaud, Anne-Françoise, Lapinte, Vincent
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't poly(2-methyl-2-oxazoline) Polymers Polyamines Micelles
Beschreibung
Zusammenfassung:In the nanomedicine field, there is a need to widen the availability of nanovectors to compensate for the increasingly reported side effects of poly(ethene glycol). Nanovectors enabling cross-linking can further optimize drug delivery. Cross-linkable polyoxazolines are therefore relevant candidates to address these two points. Here we present the synthesis of coumarin-functionalized poly(2-alkyl-2-oxazoline) block copolymers, namely, poly(2-methyl-2-oxazoline)-block-poly(2-phenyl-2-oxazoline) and poly(2-methyl-2-oxazoline)-block-poly(2-butyl-2-oxazoline). The hydrophilic ratio and molecular weights were varied in order to obtain a range of possible behaviors. Their self-assembly after nanoprecipitation or film rehydration was examined. The resulting nano-objects were fully characterized by transmission electron microscopy (TEM), cryo-TEM, multiple-angle dynamic and static light scattering. In most cases, the formation of polymer micelles was observed, as well as, in some cases, aggregates, which made characterization more difficult. Cross-linking was performed under UV illumination in the presence of a coumarin-bearing cross-linker based on polymethacrylate derivatives. Addition of the photo-cross-linker and cross-linking resulted in better-defined objects with improved stability in most cases
Beschreibung:Date Completed 28.12.2022
Date Revised 06.01.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1520-5827
DOI:10.1021/acs.langmuir.2c02896