TOR represses stress responses through global regulation of H3K27 trimethylation in plants

TOR represses stress responses through global regulation of H3K27 trimethylation in plants

© The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.

Bibliographische Detailangaben
Veröffentlicht in:Journal of experimental botany. - 1985. - 74(2023), 5 vom: 13. März, Seite 1420-1431
1. Verfasser: Dong, Yihan (VerfasserIn)
Weitere Verfasser: Uslu, Veli V, Berr, Alexandre, Singh, Gaurav, Papdi, Csaba, Steffens, Victor A, Heitz, Thierry, Ryabova, Lyubov A
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Journal of experimental botany
Schlagworte:Journal Article Research Support, Non-U.S. Gov't BRM Bistable chromatin CLF H3K27me3 H3K4me3 LHP1 biotic stress stress response mehr... target of rapamycin Histones Arabidopsis Proteins Chromatin TOR protein, Arabidopsis EC 2.7.1.137 Phosphatidylinositol 3-Kinases EC 2.7.1.-
Beschreibung
Zusammenfassung:© The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
Target of rapamycin (TOR) functions as a central sensory hub linking a wide range of external stimuli to gene expression. The mechanisms underlying stimulus-specific transcriptional reprogramming by TOR remain elusive. Here, we describe an in silico analysis in Arabidopsis demonstrating that TOR-repressed genes are associated with either bistable or silent chromatin states. Both states regulated by the TOR signaling pathway are associated with a high level of histone H3K27 trimethylation (H3K27me3) deposited by CURLY LEAF in a specific context with LIKE HETEROCHROMATIN PROTEIN1. The combination of the two epigenetic histone modifications H3K4me3 and H3K27me3 implicates a bistable feature that alternates between an 'on' and an 'off' state, allowing rapid transcriptional changes upon external stimuli. The chromatin remodeler SWI2/SNF2 ATPase BRAHMA activates TOR-repressed genes only at bistable chromatin domains to rapidly induce biotic stress responses. Here, we demonstrate both in silico and in vivo that TOR represses transcriptional stress responses through global maintenance of H3K27me3
Beschreibung:Date Completed 15.03.2023
Date Revised 04.04.2023
published: Print
Citation Status MEDLINE
ISSN:1460-2431
DOI:10.1093/jxb/erac486