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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202208251
|2 doi
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|a pubmed24n1165.xml
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|a (DE-627)NLM349642591
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|a (NLM)36451587
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Liu, Yuxin
|e verfasserin
|4 aut
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|a Ferromagnetic Flexible Electronics for Brain-Wide Selective Neural Recording
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 13.02.2023
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|a Date Revised 13.02.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Flexible microelectronics capable of straightforward implantation, remotely controlled navigation, and stable long-term recording hold great promise in diverse medical applications, particularly in deciphering complex functions of neural circuits in the brain. Existing flexible electronics, however, are often limited in bending and buckling during implantation, and unable to access a large brain region. Here, an injectable class of electronics with stable recording, omnidirectional steering, and precise navigating capabilities based on magnetic actuation is presented. After simple transcriptional injection, the rigid coatings are biodegraded quickly and the bundles of magnetic-nanoparticles-coated microelectrodes become separated, ultra-flexible, and magnetic actuated for further minimally invasive three-dimensional interpenetration in the brain. As proof of concept, this paradigm-shifting approach is demonstrated for selective and multiplexed neural activities recording across distant regions in the deep rodent brains. Coupling with optogenetic neural stimulation, the unique capabilities of this platform in electrophysiological readouts of projection dynamics in vivo are also demonstrated. The ability of these miniaturized, remotely controllable, and biocompatible ferromagnetic flexible electronics to afford minimally invasive manipulations in the soft tissues of the mammalian brain foreshadows applications in other organ systems, with great potential for broad utility in biomedical science and engineering
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|a Journal Article
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|a electrodes
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|a ferromagnetic
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|a flexible electronics
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|a neural activities
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|a Chen, Xi
|e verfasserin
|4 aut
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|a Liang, Ye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Hao
|e verfasserin
|4 aut
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1 |
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|a Yu, Peng
|e verfasserin
|4 aut
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|a Guan, Shunmin
|e verfasserin
|4 aut
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|a Liu, Zijian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Anqi
|e verfasserin
|4 aut
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| 700 |
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|a Tang, Minghui
|e verfasserin
|4 aut
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| 700 |
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|a Zhou, Yajing
|e verfasserin
|4 aut
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| 700 |
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|a Zheng, Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Zhilun
|e verfasserin
|4 aut
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| 700 |
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|a Jiang, Lelun
|e verfasserin
|4 aut
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| 700 |
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|a He, Jufang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tan, Ning
|e verfasserin
|4 aut
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| 700 |
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|a Xu, Bingzhe
|e verfasserin
|4 aut
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| 700 |
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|a Lin, Xudong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 6 vom: 14. Feb., Seite e2208251
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:35
|g year:2023
|g number:6
|g day:14
|g month:02
|g pages:e2208251
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|u http://dx.doi.org/10.1002/adma.202208251
|3 Volltext
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