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20240202231906.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202208069
|2 doi
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|a pubmed24n1278.xml
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|a (NLM)36385439
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Zhao, Fan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 13.02.2023
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|a Date Revised 02.02.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Biofilm infection has a high prevalence in chronic wounds and can delay wound healing. Current treatment using debridement and antibiotic administration imposes a significant burden on patients and healthcare systems. To address their limitations, a highly efficacious electrical antibiofilm treatment system is described in this paper. This system uses high-intensity current (75 mA cm-2 ) to completely debride biofilm above the wound surface and enhance antibiotic delivery into biofilm-infected wounds simultaneously. Combining these two effects, this system uses short treatments (≤2 h) to reduce bacterial count of methicillin-resistant S. aureus (MRSA) biofilm-infected ex vivo skin wounds from 1010 to 105.2 colony-forming units (CFU) g-1 . Taking advantage of the hydrogel ionic circuit design, this system enhances the in vivo safety of high-intensity current application compared to conventional devices. The in vivo antibiofilm efficacy of the system is tested using a diabetic mouse-based wound infection model. MRSA biofilm bacterial count decreases from 109.0 to 104.6 CFU g-1 at 1 day post-treatment and to 103.3 CFU g-1 at 7 days post-treatment, both of which are below the clinical threshold for infection. Overall, this novel technology provides a quick, safe, yet highly efficacious treatment to chronic wound biofilm infections
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|a Journal Article
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|a biofilm
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|a chronic wound infection
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|a electrical debridement
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|a hydrogel ionic circuit
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|a iontophoretic antibiotic delivery
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|a Anti-Bacterial Agents
|2 NLM
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| 700 |
1 |
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|a Su, Yajuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Junying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Romanova, Svetlana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a DiMaio, Dominick J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Jingwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Siwei
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 6 vom: 01. Feb., Seite e2208069
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|g volume:35
|g year:2023
|g number:6
|g day:01
|g month:02
|g pages:e2208069
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|u http://dx.doi.org/10.1002/adma.202208069
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