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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c02474
|2 doi
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|a pubmed24n1162.xml
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|a (DE-627)NLM348639953
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|a (NLM)36350293
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Zhang, Xiaolei
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Multifunctional Bi NSsBSA Nanoplatform Guided by CT Imaging for Effective Photothermal Therapy
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| 264 |
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|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 29.11.2022
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|a Date Revised 23.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Photothermal therapy (PTT) has attracted great attention as an anticancer treatment strategy. With the rapid development of nanomedicine, multifunctional inorganic nanophotothermal agents provide a new way to improve the effect of PTT. Herein, bovine serum albumin (BSA)-modified Bi nanosheets (Bi NSs) with good biocompatibility were synthesized by a facile redox and ball milling method and applied as a photothermal agent for the enhancement of PTT. Owing to the strong near-infrared absorption, Bi NSs exhibit high photothermal conversion efficiency (η = 36.17%) under 808 nm laser irradiation and can serve as a nanotherapeutic agent for cancer therapy. In addition, in vitro cell safety analysis also suggests that the toxicity of BSA-modified Bi NSs is negligible. Upon 808 nm irradiation, the uptake ability of tumor cells to Bi NSsBSA has been improved. Moreover, Bi NSs@BSA also can be used as a good contrast agent for CT imaging and then to observe the distribution of materials in the tumor site. Finally, Bi NSs@BSA-mediated PTT results show a high ablation rate of A549 tumor cells both in vitro and in vivo. All results reveal that Bi NSs@BSA is a promising nanotherapeutic platform for PTT
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Serum Albumin, Bovine
|2 NLM
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|a 27432CM55Q
|2 NLM
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|a Bismuth
|2 NLM
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|a U015TT5I8H
|2 NLM
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| 700 |
1 |
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|a Liu, Bin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Shu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Zongming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jinkai
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 38(2022), 46 vom: 22. Nov., Seite 14355-14363
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:38
|g year:2022
|g number:46
|g day:22
|g month:11
|g pages:14355-14363
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|u http://dx.doi.org/10.1021/acs.langmuir.2c02474
|3 Volltext
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