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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c02376
|2 doi
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|a pubmed25n1161.xml
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|a (DE-627)NLM348566808
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|a (NLM)36342842
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|a eng
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|a Hu, Yanlei
|e verfasserin
|4 aut
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|a Formulation of Silk Fibroin Nanobrush-Stabilized Biocompatible Pickering Emulsions
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 23.11.2022
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|a Date Revised 23.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Silk fibroin is widely believed to be sustainable, biocompatible, and biodegradable, providing promising features such as carriers to deliver drugs and functional ingredients in food, personal care, and biomedical areas, which are consistent with emulsion characteristics; especially, green, all-natural biopolymer-based stabilizers are in great demand to stabilize Pickering emulsions and match the multifunctional needs for developing ideal materials. Herein, an unprecedented three-dimensional (3D) nanostructure, namely a brush-like silk nanobrush (SNB), is applied as the stabilizer to formulate and stabilize Pickering emulsions. The size and interfacial tension are compared among the SNB, a regenerated silk nanofiber, and a nanowhisker. Additionally, optimization processes are conducted to determine the ideal ultrasonication intensity and SNB concentration required to prepare Pickering emulsions by analyzing the morphology, creaming index, mean oil droplet size, and rheological behavior. The results indicate that an SNB with the characteristic structure and suitable size shows superior potential to form sophisticated and interconnected networks in oil-water interfaces, and is proved to be able to resist creaming at a wide range of concentrations and subsequently stabilize Pickering emulsions from liquid-like emulsions to gel-like emulsions. Additionally, SNB is proved to be biocompatible according to cell experiments, providing a promising alternative in designing all-natural, green, and biocompatible emulsions with the aim of efficiently delivering nutrients or drugs associated with health benefits
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Emulsions
|2 NLM
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|a Fibroins
|2 NLM
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|a 9007-76-5
|2 NLM
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|a Water
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|a 059QF0KO0R
|2 NLM
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| 700 |
1 |
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|a Zou, Yujun
|e verfasserin
|4 aut
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1 |
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|a Ma, Yue
|e verfasserin
|4 aut
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| 700 |
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|a Yu, Juan
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Liang
|e verfasserin
|4 aut
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|a Chen, Meijuan
|e verfasserin
|4 aut
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|a Ling, Shengjie
|e verfasserin
|4 aut
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|a Fan, Yimin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 38(2022), 46 vom: 22. Nov., Seite 14302-14312
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
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|g volume:38
|g year:2022
|g number:46
|g day:22
|g month:11
|g pages:14302-14312
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|u http://dx.doi.org/10.1021/acs.langmuir.2c02376
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