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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2022.109170
|2 doi
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|a pubmed24n1161.xml
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|a (DE-627)NLM348501978
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|a (NLM)36336331
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|a (PII)S1521-6616(22)00251-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Parackova, Zuzana
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Immunomodulation of neutrophils and platelets by TNF blockage in patients with juvenile idiopathic arthritis
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 25.11.2022
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|a Date Revised 26.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Juvenile idiopathic arthritis (JIA) is a multifactorial autoimmune disease mediated by both adaptive and innate immunity. The role of neutrophils in the pathogenesis of autoimmune diseases is well-established; however, in JIA they are still markedly understudied. Here, we explored the neutrophil features and role of platelet-neutrophil aggregates in JIA patients and assessed the effect of TNF inhibitor (TNFi) therapy. We provide evidence of dysbalanced neutrophil subsets in JIA patients, with a shift towards immature and suppressive subpopulations that lack the cell-adhesion molecules. Correspondingly, patient sera contained high amounts of neutrophil- and platelet-related products. Transcriptomic analysis revealed neutrophil degranulation as the most affected process by TNFi therapy, which was mirrored by the decrease in degranulation products in the patient sera. Toll-like receptors -4, -7, and - 8 signaling pathways are particularly hyperresponsive in patients, but are strongly suppressed by TNFi. Overall, our study demonstrates augmented neutrophil and platelet responses in JIA patients
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Juvenile idiopathic arthritis
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| 650 |
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4 |
|a MMP8
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| 650 |
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4 |
|a Neutrophil
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| 650 |
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|a Neutrophil-platelet aggregates
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| 650 |
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|a Platelet
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| 650 |
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4 |
|a S100
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| 650 |
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4 |
|a TNF inhibitors
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| 700 |
1 |
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|a Zentsova, Irena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Horvath, Rudolf
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Malcova, Hana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cebecauerova, Dita
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sediva, Anna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Klocperk, Adam
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 245(2022) vom: 15. Dez., Seite 109170
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:245
|g year:2022
|g day:15
|g month:12
|g pages:109170
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|u http://dx.doi.org/10.1016/j.clim.2022.109170
|3 Volltext
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