Model Lipid Raft Membranes for Embedding Integral Membrane Proteins : Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins
For the first time, HMG-CoA reductase, the membrane protein responsible for cholesterol synthesis, was incorporated into a lipid membrane consisting of DOPC:Chol:SM at a 1:1:1 molar ratio, which mimics the lipid rafts of cell membranes. The membrane containing the protein was generated in the form o...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 38(2022), 45 vom: 15. Nov., Seite 13888-13897 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2022
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Hydroxymethylglutaryl-CoA Reductase Inhibitors 3-hydroxy-3-methylglutaryl-coenzyme A 1553-55-5 Membrane Proteins Liposomes Fluvastatin 4L066368AS Water |
| Online verfügbar |
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