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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202207198
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|a eng
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| 100 |
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|a Zhu, Xiaoqiang
|e verfasserin
|4 aut
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|a Near-Infrared Nano-Optogenetic Activation of Cancer Immunotherapy via Engineered Bacteria
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|c 2023
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|a Text
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|a ƒaComputermedien
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|a Date Completed 27.02.2023
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|a Date Revised 27.02.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Certain anaerobic microbes with the capability to colonize the tumor microenvironment tend to express the heterologous gene in a sustainable manner, which will inevitably compromise the therapeutic efficacy and induce off-tumor toxicity in vivo. To improve the therapeutic precision and controllability of bacteria-based therapeutics, Escherichia coli Nissle 1917 (EcN), engineered to sense blue light and release the encoded flagellin B (flaB), is conjugated with lanthanide upconversion nanoparticles (UCNPs) for near-infrared (NIR) nano-optogenetic cancer immunotherapy. Upon 808 nm photoirradiation, UCNPs emit at the blue region to photoactivate the EcN for secretion of flaB, which subsequently binds to Toll-like receptor 5 expressed on the membrane of macrophages for activating immune response via MyD88-dependent signal pathway. Such synergism leads to significant tumor regression in different tumor models and metastatic tumors with negligible side effects. These studies based on the NIR nano-optogenetic platform highlight the rational of leveraging the optogenetic tools combined with natural propensity of certain bacteria for cancer immunotherapy
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|a Journal Article
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|a cancer immunotherapy
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|a engineered bacteria
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|a lanthanide upconversion nanoparticles
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|a nano-optogenetics
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|a Chen, Sihan
|e verfasserin
|4 aut
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1 |
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|a Hu, Xiuwen
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Lijun
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Yiqian
|e verfasserin
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| 700 |
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|a Huang, Jinzhao
|e verfasserin
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| 700 |
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|a Chen, Jiawen
|e verfasserin
|4 aut
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| 700 |
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|a Qiu, Yuzhi
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Xuefei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Mengdie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Xiangliang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Yanhong
|e verfasserin
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 35(2023), 8 vom: 26. Feb., Seite e2207198
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