An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 50 vom: 22. Dez., Seite e2207870
1. Verfasser:	Yin, Zhiwei (VerfasserIn)
Weitere Verfasser:	Shi, Rui, Xia, Xin, Li, Ling, Yang, Yanxia, Li, Shengkai, Xu, Jieqiong, Xu, Yiting, Cai, Xinqi, Wang, Shen, Liu, Zhangkun, Peng, Tianhuan, Peng, Ying, Wang, Hua, Ye, Mao, Liu, Yanlan, Chen, Zhuo, Tan, Weihong
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article adhesion repertoires bioinspired ultrastructure circulating tumor cell removal magnetothermal response vascular-like integrated trapped devices

Beschreibung
Zusammenfassung:	© 2022 Wiley-VCH GmbH. An integrated trapped device (ITD) capable of removal of circulating tumor cells (CTCs) can assuage or even prevent metastasis. However, adhesion repertoires are ordinarily neglected in the design of ITDs, possibly leading to the omission of highly metastatic CTC and treatment failure. Here a vascular-like ITD with adhesive sites and wireless magnetothermal response to remove highly metastatic CTC in vivo is presented. Such a vascular-like ITD comprises circumferential well-aligned fibers and artificial adhesion repertoires and is optimized for magnetothermal integration. Continuous and repeated capture in a dynamic environment increases capture efficiency over time. Meanwhile, the heat generation of the ITD leads to the capture of CTC death owing to cell heat sensitivity. Furthermore, the constructed bioinspired ultrastructure of the ITD prevents vascular blockage and induces potential vascular regeneration. Overall, this work defines an extendable strategy for constructing adhesion repertoires against intravascular shear forces, provides a vascular-like ITD for reducing CTC counts, and is expected to alleviate the risk of cancer recurrence
Beschreibung:	Date Completed 20.12.2022 Date Revised 22.12.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202207870