Photoswitchable Microgels for Dynamic Macrophage Modulation

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 49 vom: 04. Dez., Seite e2205498
1. Verfasser:	Kim, Yuri (VerfasserIn)
Weitere Verfasser:	Thangam, Ramar, Yoo, Jounghyun, Heo, Jeongyun, Park, Jung Yeon, Kang, Nayeon, Lee, Sungkyu, Yoon, Jiwon, Mun, Kwang Rok, Kang, Misun, Min, Sunhong, Kim, Seong Yeol, Son, Subin, Kim, Jihwan, Hong, Hyunsik, Bae, Gunhyu, Kim, Kanghyeon, Lee, Sanghyeok, Yang, Letao, Lee, Ja Yeon, Kim, Jinjoo, Park, Steve, Kim, Dong-Hyun, Lee, Ki-Bum, Jang, Woo Young, Kim, Bong Hoon, Paulmurugan, Ramasamy, Cho, Seung-Woo, Song, Hyun-Cheol, Kang, Seok Ju, Sun, Wujin, Zhu, Yangzhi, Lee, Junmin, Kim, Han-Jun, Jang, Ho Seong, Kim, Jong Seung, Khademhosseini, Ali, Kim, Yongju, Kim, Sehoon, Kang, Heemin
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article dynamic hydrogels macrophage adhesion macrophage polarization microgel swelling photoswitchable microgels Microgels

Beschreibung
Zusammenfassung:	© 2022 Wiley-VCH GmbH. Dynamic manipulation of supramolecular self-assembled structures is achieved irreversibly or under non-physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed of azobenzene derivatives stacked via π-cation and π-π interactions are developed that are electrostatically stabilized with Arg-Gly-Asp (RGD)-bearing anionic polymers. Lateral swelling of RGD-bearing microgels occurs via cis-azobenzene formation mediated by near-infrared-light-upconverted ultraviolet light, which disrupts intermolecular interactions on the visible-light-absorbing upconversion-nanoparticle-coated materials. Real-time imaging and molecular dynamics simulations demonstrate the deswelling of RGD-bearing microgels via visible-light-mediated trans-azobenzene formation. Near-infrared light can induce in situ swelling of RGD-bearing microgels to increase RGD availability and trigger release of loaded interleukin-4, which facilitates the adhesion structure assembly linked with pro-regenerative polarization of host macrophages. In contrast, visible light can induce deswelling of RGD-bearing microgels to decrease RGD availability that suppresses macrophage adhesion that yields pro-inflammatory polarization. These microgels exhibit high stability and non-toxicity. Versatile use of ligands and protein delivery can offer cytocompatible and photoswitchable manipulability of diverse host cells
Beschreibung:	Date Completed 15.12.2022 Date Revised 15.12.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202205498