Coordinated regulation of plant defense and autoimmunity by paired trihelix transcription factors ASR3/AITF1 in Arabidopsis

Coordinated regulation of plant defense and autoimmunity by paired trihelix transcription factors ASR3/AITF1 in Arabidopsis

© 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 237(2023), 3 vom: 20. Feb., Seite 914-929
1. Verfasser: Wang, Ying (VerfasserIn)
Weitere Verfasser: Tang, Meng, Zhang, Ying, Huang, Mengling, Wei, Lan, Lin, Yang, Xie, Jiatao, Cheng, Jiasen, Fu, Yanping, Jiang, Daohong, Li, Bo, Yu, Xiao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Arabidopsis thaliana NLR gene expression autoimmunity immune gene expression pattern-triggered immunity trihelix transcription factor Arabidopsis Proteins ASR3 protein, Arabidopsis mehr... Transcription Factors, General AT4G36150 protein, Arabidopsis VFP3 protein, Arabidopsis
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520 |a Plants perceive pathogens and induce robust transcriptional reprogramming to rapidly achieve immunity. The mechanisms of how immune-related genes are transcriptionally regulated remain largely unknown. Previously, the trihelix transcriptional factor ARABIDOPSIS SH4-RELATED 3 (ASR3) was shown to negatively regulate pattern-triggered immunity (PTI) in Arabidopsis thaliana. Here, we identified another trihelix family member ASR3-Interacting Transcriptional Factor 1 (AITF1) as an interacting protein of ASR3. ASR3-Interacting Transcriptional Factor 1 and ASR3 form heterogenous and homogenous dimers in planta. Both aitf1 and asr3 single mutants exhibited increased resistance against the bacterial pathogen Pseudomonas syringae, but the double mutant showed reduced resistance, suggesting AITF1 and ASR3 interdependently regulate immune gene expression and resistance. Overexpression of AITF1 triggered autoimmunity dependently on its DNA-binding ability and the presence of ASR3. Notably, autoimmunity caused by overexpression of AITF1 was dependent on a TIR-NBS-LRR (TNL) protein suppressor of AITF1-induced autoimmunity 1 (SAA1), as well as enhanced disease susceptibility 1 (EDS1), the central regulator of TNL signaling. ASR3-Interacting Transcriptional Factor 1 and ASR3 directly activated SAA1 expression through binding to the GT-boxes in SAA1 promoter. Collectively, our results revealed a mechanism of trihelix transcription factor complex in regulating immune gene expression, thereby modulating plant disease resistance and autoimmunity 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Arabidopsis thaliana 
650 4 |a NLR gene expression 
650 4 |a autoimmunity 
650 4 |a immune gene expression 
650 4 |a pattern-triggered immunity 
650 4 |a trihelix transcription factor 
650 7 |a Arabidopsis Proteins  |2 NLM 
650 7 |a ASR3 protein, Arabidopsis  |2 NLM 
650 7 |a Transcription Factors, General  |2 NLM 
650 7 |a AT4G36150 protein, Arabidopsis  |2 NLM 
650 7 |a VFP3 protein, Arabidopsis  |2 NLM 
700 1 |a Tang, Meng  |e verfasserin  |4 aut 
700 1 |a Zhang, Ying  |e verfasserin  |4 aut 
700 1 |a Huang, Mengling  |e verfasserin  |4 aut 
700 1 |a Wei, Lan  |e verfasserin  |4 aut 
700 1 |a Lin, Yang  |e verfasserin  |4 aut 
700 1 |a Xie, Jiatao  |e verfasserin  |4 aut 
700 1 |a Cheng, Jiasen  |e verfasserin  |4 aut 
700 1 |a Fu, Yanping  |e verfasserin  |4 aut 
700 1 |a Jiang, Daohong  |e verfasserin  |4 aut 
700 1 |a Li, Bo  |e verfasserin  |4 aut 
700 1 |a Yu, Xiao  |e verfasserin  |4 aut 
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