A new isolate of Streptomyces lateritius (Z1-26) with antibacterial activity against fish pathogens and immune enhancement effects on crucian carp (Carassius auratus)

© 2022 John Wiley & Sons Ltd.

Bibliographische Detailangaben
Veröffentlicht in:Journal of fish diseases. - 1998. - 46(2023), 2 vom: 28. Feb., Seite 99-112
1. Verfasser: Yang, Yahui (VerfasserIn)
Weitere Verfasser: Jin, Duo, Long, Wensu, Lai, Ximiao, Sun, Yunjun, Zhai, Feng, Wang, Pan, Zhou, Xixun, Hu, Yibo, Xia, Liqiu, Yi, Ganfeng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Journal of fish diseases
Schlagworte:Journal Article Carassius auratus antibacterial activity genome sequencing growth immune response Kelch-Like ECH-Associated Protein 1 Antioxidants NF-E2-Related Factor 2 Anti-Bacterial Agents Fish Proteins
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245 1 2 |a A new isolate of Streptomyces lateritius (Z1-26) with antibacterial activity against fish pathogens and immune enhancement effects on crucian carp (Carassius auratus) 
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520 |a The Streptomyces lateritius Z1-26 was isolated from soil samples which showed broad-spectrum antibacterial activity against a broad range of fish pathogens. The In Vivo Imaging System (IVIS) monitored that strain Z1-26 could survive and colonize in the gills and abdomen of crucian carp. The effects of dietary supplementation with strain Z1-26 were evaluated with respect to the growth performance, antioxidant capacity, and immune response of crucian carp. The results showed that the Z1-26-fed fish had a significantly higher growth rate than the fish fed the control diet. The immune and antioxidant parameters revealed that the non-specific immune indicators (AKP, SOD, and LZM) of the serum, the expression of immune-related genes (IgM, C3, and LZM), and antioxidant-related genes (Nrf2 and Keap1) of the immune organs were significantly increased, whereas the expression of pro-inflammatory factors (IL-1β, IL-8, and TNF-α) of the immune organs was significantly down-regulated in crucian carp fed strain Z1-26 compared with fish fed a control diet. Moreover, fish fed with Z1-26 supplemented diets showed a significantly improved survival rate after Aeromonas hydrophila infection. In addition, the whole genome analysis showed that strain Z1-26 possesses 28 gene clusters, including 6 polyketide synthetase (PKS), 4 non-ribosomal peptide-synthetase (NRPS), 1 bacteriocin, and 1 lantipeptide. In summary, these results indicated that strain Z1-26 could improve the growth performance and disease resistance in crucian carp, and has the potential to be developed as a candidate probiotics for the control of bacterial diseases in aquaculture 
650 4 |a Journal Article 
650 4 |a Carassius auratus 
650 4 |a antibacterial activity 
650 4 |a genome sequencing 
650 4 |a growth 
650 4 |a immune response 
650 7 |a Kelch-Like ECH-Associated Protein 1  |2 NLM 
650 7 |a Antioxidants  |2 NLM 
650 7 |a NF-E2-Related Factor 2  |2 NLM 
650 7 |a Anti-Bacterial Agents  |2 NLM 
650 7 |a Fish Proteins  |2 NLM 
700 1 |a Jin, Duo  |e verfasserin  |4 aut 
700 1 |a Long, Wensu  |e verfasserin  |4 aut 
700 1 |a Lai, Ximiao  |e verfasserin  |4 aut 
700 1 |a Sun, Yunjun  |e verfasserin  |4 aut 
700 1 |a Zhai, Feng  |e verfasserin  |4 aut 
700 1 |a Wang, Pan  |e verfasserin  |4 aut 
700 1 |a Zhou, Xixun  |e verfasserin  |4 aut 
700 1 |a Hu, Yibo  |e verfasserin  |4 aut 
700 1 |a Xia, Liqiu  |e verfasserin  |4 aut 
700 1 |a Yi, Ganfeng  |e verfasserin  |4 aut 
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