Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO2
This work gives an insight into the process of adsorptive drug loading in silica aerogels from supercritical CO2 (scCO2). A prevalent method for such loading entails bringing the aerogels into contact with the drug-scCO2 solution followed by slow or isothermal depressurization. Our previous work est...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 38(2022), 43 vom: 01. Nov., Seite 13075-13083 |
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| Weitere Verfasser: | , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2022
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Silicon Dioxide 7631-86-9 Carbon Dioxide 142M471B3J Fenofibrate U202363UOS Ibuprofen WK2XYI10QM |
| Zusammenfassung: | This work gives an insight into the process of adsorptive drug loading in silica aerogels from supercritical CO2 (scCO2). A prevalent method for such loading entails bringing the aerogels into contact with the drug-scCO2 solution followed by slow or isothermal depressurization. Our previous work established that drug precipitates during depressurization. Consequently, the adsorptive drug loading measured by the prevalent method includes precipitation. An alternative method is presented for accurate measurement of adsorption avoiding precipitation. To illustrate the disparity between the two methods, the concentration dependence of drug loadings in scCO2, obtained by both methods, is compared for fenofibrate, ibuprofen, and benzoic acid. A mechanism is proposed, and a mathematical model is developed for comparing the adsorptive drug loadings by both methods. The loading obtained by the present method is found to be much less than that by the prevalent method, though both correlate well with the formalism of the Langmuir adsorption equation with the same equilibrium constant at low concentrations. Equations are developed for the concentration dependence of drug loadings measured by both methods at all concentrations in scCO2 |
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| Beschreibung: | Date Completed 02.11.2022 Date Revised 15.12.2022 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/acs.langmuir.2c01694 |