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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-022-02594-8
|2 doi
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|a pubmed24n1157.xml
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|a (NLM)36208366
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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|a Martyniuk, Viktoria
|e verfasserin
|4 aut
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|a Stress responses of bivalve mollusc Unio tumidus from two areas to ibuprofen, microplastic and their mixture
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.11.2022
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|a Date Revised 15.11.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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|a Even though bivalve molluscs are recognized as bioindicators of freshwater quality, their responses to multiple stressors are unpredictable. This study aims to elucidate the inter-population peculiarities of the effect in the sub-chronic environmentally relevant exposure to novel contaminants. The specimens of Unio tumidus from reference (Pr) and contaminated (Ct) areas were treated with ibuprofen (IBU, 0.8 µg L-1), microplastic (MP, 1.0 mg L-1, size 0.1-0.5 mm), or their combination (Mix) for 14 days. Untreated mussels (PrC- and CtC-groups) served as controls. The PrC-group had higher levels of antioxidants Mn-SOD, Cu,Zn-SOD, catalase, and cholinesterase (AChE) as well as lesser levels of oxidative lesions (TBARS and protein carbonyls) in digestive glands, indicating lower environmental impact than in the CtC-group. However, lysosomal stability was similar in both control groups. Among antioxidants, Mn-SOD activity was affected most prominently, increasing in all exposed Ct-groups. TBARS level was increased only in PrMP-group compared to responsive control. IBU and Mix enhanced protein carbonyl concentration in the Pr-groups, and decreased it in the Ct-groups. AChE was induced in the CtIBU- and PrMix-groups, and lysosomal integrity increased in the CtIBU and CtMix-groups. Discriminant analyses indicated lesser differences between Pr-groups, demonstrating lower cumulative stress compared to Ct-groups. Generally, the most remarkable response was revealed in the CtIBU-group, and distortion of individual effects was established in combined exposures. The qualification of stress-neutral and stress-positive populations was proposed for Pr- and Ct-populations correspondingly. Inter-site peculiarities must be taken into consideration when the environmental impact of MP and pharmaceuticals is evaluated
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|a Journal Article
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|a Bivalve mollusk
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|a Inter-site variability
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|a Microplastics
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|a NSAIDs
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|a Oxidative stress
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|a Toxicity
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|a Microplastics
|2 NLM
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|a Ibuprofen
|2 NLM
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| 650 |
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|a WK2XYI10QM
|2 NLM
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| 650 |
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|a Plastics
|2 NLM
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|a Antioxidants
|2 NLM
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|a Thiobarbituric Acid Reactive Substances
|2 NLM
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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|a Superoxide Dismutase
|2 NLM
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| 650 |
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|a EC 1.15.1.1
|2 NLM
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1 |
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|a Gylytė, Brigita
|e verfasserin
|4 aut
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|a Matskiv, Tetiana
|e verfasserin
|4 aut
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|a Khoma, Vira
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|a Tulaidan, Halyna
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|a Gnatyshyna, Lesya
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|a Orlova-Hudim, Kateryna
|e verfasserin
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|a Manusadžianas, Levonas
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|a Stoliar, Oksana
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 31(2022), 9 vom: 08. Nov., Seite 1369-1381
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:31
|g year:2022
|g number:9
|g day:08
|g month:11
|g pages:1369-1381
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|u http://dx.doi.org/10.1007/s10646-022-02594-8
|3 Volltext
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