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|a 10.1155/2022/4714763
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|a eng
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|a Tang, Yi
|e verfasserin
|4 aut
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|a Resting-State fMRI Whole Brain Network Function Plasticity Analysis in Attention Deficit Hyperactivity Disorder
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|c 2022
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|a Date Completed 07.10.2022
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|a Date Revised 28.10.2022
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|a published: Electronic-eCollection
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|a Citation Status MEDLINE
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|a Copyright © 2022 Yi Tang et al.
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|a Attention deficit hyperactivity disorder (ADHD) is a common mental disorder in children, which is related to inattention and hyperactivity. These symptoms are associated with abnormal interactions of brain networks. We used resting-state functional magnetic resonance imaging (rs-fMRI) based on the graph theory to explore the topology property changes of brain networks between an ADHD group and a normal group. The more refined AAL_1024 atlas was used to construct the functional networks with high nodal resolution, for detecting more subtle changes in brain regions and differences among groups. We compared altered topology properties of brain network between the groups from multilevel, mainly including modularity at mesolevel. Specifically, we analyzed the similarities and differences of module compositions between the two groups. The results found that the ADHD group showed stronger economic small-world network property, while the clustering coefficient was significantly lower than the normal group; the frontal and occipital lobes showed smaller node degree and global efficiency between disease statuses. The modularity results also showed that the module number of the ADHD group decreased, and the ADHD group had short-range overconnectivity within module and long-range underconnectivity between modules. Moreover, modules containing long-range connections between the frontal and occipital lobes disappeared, indicating that there was lack of top-down control information between the executive control region and the visual processing region in the ADHD group. Our results suggested that these abnormal regions were related to executive control and attention deficit of ADHD patients. These findings helped to better understand how brain function correlates with the ADHD symptoms and complement the fewer modularity elaboration of ADHD research
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Zheng, Shuxing
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|a Tian, Yin
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2022(2022) vom: 08., Seite 4714763
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|g volume:2022
|g year:2022
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