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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202206594
|2 doi
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|a pubmed25n1156.xml
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|a (DE-627)NLM347092268
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|a (NLM)36193773
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|a DE-627
|b ger
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|e rakwb
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|a eng
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|a Liu, Kanglei
|e verfasserin
|4 aut
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|a Triarylboron-Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 15.12.2022
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|a Date Revised 15.12.2022
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field of cancer treatment. Herein, a new strategy for the development of efficient organic sonosensitizers based on triarylboron-doped acenethiophene scaffolds is presented. The attachment of boron to the linear acenethiophenes lowers the lowest unoccupied molecular orbital (LUMO) energy, resulting in redshifted absorptions and emissions. After encapsulation with the amphiphilic polymer DSPE-mPEG2000 , it is found that the nanostructured BAnTh-NPs and BTeTh-NPs (nanoparticles of BAnTh and BTeTh) shows efficient hydroxyl radical (• OH) generation under ultrasound (US) irradiation in aqueous solution with almost no phototoxicity, which can overcome the shortcomings of O2 -dependent SDT and avoid the potential cutaneous phototoxicity issue. In vitro and in vivo therapeutic results validate that boron-doped acenethiophenes as sonosensitizers enable high SDT efficiency with low phototoxicity and good biocompatibility, indicating that boron-functionalization of acenes is a promising strategy toward organic sonosensitizers for SDT
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|a Journal Article
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|a heteroacenes
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|a hydroxyl radicals
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|a sonodynamic therapy
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|a sonosensitizers
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|a triarylboron
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|a Jiang, Zhenqi
|e verfasserin
|4 aut
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1 |
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|a Zhao, Fenggui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Weizhi
|e verfasserin
|4 aut
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|a Jäkle, Frieder
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Nan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Xiaoying
|e verfasserin
|4 aut
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|a Yin, Xiaodong
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Pangkuan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 49 vom: 01. Dez., Seite e2206594
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:34
|g year:2022
|g number:49
|g day:01
|g month:12
|g pages:e2206594
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|u http://dx.doi.org/10.1002/adma.202206594
|3 Volltext
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