Positive rates of interferon-γ release assay and tuberculin skin test in detection of latent tuberculosis infection A systematic review and meta-analysis of 200,000 head-to-head comparative tests

Positive rates of interferon-γ release assay and tuberculin skin test in detection of latent tuberculosis infection : A systematic review and meta-analysis of 200,000 head-to-head comparative tests

Copyright © 2022 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 245(2022) vom: 15. Dez., Seite 109132
1. Verfasser: Zhou, Guozhong (VerfasserIn)
Weitere Verfasser: Luo, Qingyi, Luo, Shiqi, He, Jian, Chen, Nan, Zhang, Yu, Yang, Rui, Qiu, Yubing, Li, Shenghao, Ping, Qinrong, Cai, Shunli, Guo, Xin, Song, Chao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Meta-Analysis Systematic Review Journal Article Research Support, Non-U.S. Gov't Head-to-head comparison Interferon-γ release assay Latent tuberculosis infection Positive rate Tuberculin skin test BCG Vaccine
Beschreibung
Zusammenfassung:Copyright © 2022 Elsevier Inc. All rights reserved.
OBJECTIVE: To compare the positive rates of IGRA and TST in detection of LTBI
METHODS: We searched PubMed, Embase, and the Cochrane Library on March 12, 2022. A random-effects model was used to calculate pooled results
RESULTS: We included 458 head-to-head studies. Compared with immunocompetent controls, TST positive rate in immunosuppressed population decreased more than IGRA positive rate (OR 0.36 [95% CI: 0.31 to 0.41] versus 0.53 [0.46 to 0.61]). In immunocompetent BCG-vaccinated individuals, IGRA positive rate in low-TB burden areas was significantly lower than TST positive rate, but the difference was decreased in high-TB burden areas (OR 0.75 [0.60 to 0.94]). Additionally, IGRA positive rate was equal to that of TST in the elderly (OR 0.98 [0.66 to 1.46])
CONCLUSION: TST is more susceptible to immunosuppression than IGRA. The effect of BCG on TST might be weakened in high-TB burden areas, and TST response waned in the elderly
REVIEW REGISTRATION: PROSPERO CRD42020180163
Beschreibung:Date Completed 25.11.2022
Date Revised 26.12.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2022.109132