Citrullination : A modification important in the pathogenesis of autoimmune diseases
Copyright © 2022 Elsevier Inc. All rights reserved.
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 245(2022) vom: 15. Dez., Seite 109134 |
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| Auteur principal: | |
| Autres auteurs: | , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2022
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Review Research Support, Non-U.S. Gov't Autoimmune diseases Citrullination Immune cells Neutrophil extracellular traps Peptidyl arginine deiminase Protein-Arginine Deiminases EC 3.5.3.15 plus... |
| Résumé: | Copyright © 2022 Elsevier Inc. All rights reserved. Peptidyl arginine deiminase (PAD) which mediates citrullination catalyzes the conversion of arginine residues of protein peptide chains to citrulline residues. Citrullination can be involved in the process of apoptosis, embryo development, regulation of myelin sheath function and other physiological processes. Besides, it can regulate the process of cell death, affect the formation of neutrophil extracellular traps (NETs) and produce anti-citrullinated protein antibody (ACPA) to participate in autoimmune diseases. In this manuscript, the regulatory effects of citrullination in normal physiology and autoimmune diseases are reviewed, and the effects of citrullination on immune cells in autoimmune diseases are discussed in detail |
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| Description: | Date Completed 25.11.2022 Date Revised 26.12.2022 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2022.109134 |