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|a 10.1021/acs.langmuir.2c01715
|2 doi
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|a pubmed25n1154.xml
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|a (NLM)36126324
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|a eng
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| 100 |
1 |
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|a Gamage, Rananjaya S
|e verfasserin
|4 aut
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| 245 |
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|a Spontaneous Transfer of Indocyanine Green from Liposomes to Albumin Is Inhibited by the Antioxidant α-Tocopherol
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|c 2022
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 05.10.2022
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|a Date Revised 07.02.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Indocyanine Green (ICG) is a clinically approved organic dye with near-infrared absorption and fluorescence. Over the years, many efforts to improve the photophysical and pharmacokinetic properties of ICG have investigated numerous nanoparticle formulations, especially liposomes with membrane-embedded ICG. A series of systematic absorption and fluorescence experiments, including FRET experiments using ICG as a fluorescence energy acceptor, found that ICG transfers spontaneously from liposomes to albumin protein residing in the external solution with a half-life of ∼10 min at 37 °C. Moreover, transfer of ICG from liposome membranes to external albumin reduces light-activated leakage from thermosensitive liposomes with membrane-embedded ICG. A survey of lipophilic liposome additives discovered that the presence of clinically approved antioxidant, α-tocopherol, greatly increases ICG retention in the liposomes (presumably by forming favorable aromatic stacking interactions), inhibits ICG photobleaching and prevents albumin-induced reduction of light-triggered liposome leakage. This new insight will help researchers with the specific task of optimizing ICG-containing liposomes for fluorescence imaging or phototherapeutics. More broadly, the results suggest a broader design concept concerning light triggered liposome leakage, that is, proximity of the light absorbing dye to the bilayer membrane is a critical design feature that impacts the extent of liposome leakage
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Albumins
|2 NLM
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|a Antioxidants
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|a Liposomes
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|a alpha-Tocopherol
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|a Indocyanine Green
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|a Smith, Bradley D
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|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 38(2022), 39 vom: 04. Okt., Seite 11950-11961
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|x 1520-5827
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|g volume:38
|g year:2022
|g number:39
|g day:04
|g month:10
|g pages:11950-11961
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|u http://dx.doi.org/10.1021/acs.langmuir.2c01715
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