Rapid Regeneration of a Neoartery with Elastic Lamellae

Rapid Regeneration of a Neoartery with Elastic Lamellae

© 2022 The Authors. Advanced Materials published by Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 47 vom: 01. Nov., Seite e2205614
1. Verfasser: Wang, Ziyu (VerfasserIn)
Weitere Verfasser: Mithieux, Suzanne M, Vindin, Howard, Wang, Yiwei, Zhang, Miao, Liu, Linyang, Zbinden, Jacob, Blum, Kevin M, Yi, Tai, Matsuzaki, Yuichi, Oveissi, Farshad, Akdemir, Reyda, Lockley, Karen M, Zhang, Lingyue, Ma, Ke, Guan, Juan, Waterhouse, Anna, Pham, Nguyen T H, Hawkett, Brian S, Shinoka, Toshiharu, Breuer, Christopher K, Weiss, Anthony S
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article elastic lamellae elastin internal elastic lamina polyglycerol sebacate regenerative medicine tissue engineering tropoelastin vascular grafts Elastin mehr... 9007-58-3 Collagen 9007-34-5
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100 1 |a Wang, Ziyu  |e verfasserin  |4 aut 
245 1 0 |a Rapid Regeneration of a Neoartery with Elastic Lamellae 
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500 |a Date Completed 25.11.2022 
500 |a Date Revised 15.12.2023 
500 |a published: Print-Electronic 
500 |a ErratumIn: Adv Mater. 2024 Jan;36(4):e2312063. doi: 10.1002/adma.202312063. - PMID 38102082 
500 |a Citation Status MEDLINE 
520 |a © 2022 The Authors. Advanced Materials published by Wiley-VCH GmbH. 
520 |a Native arteries contain a distinctive intima-media composed of organized elastin and an adventitia containing mature collagen fibrils. In contrast, implanted biodegradable small-diameter vascular grafts do not present spatially regenerated, organized elastin. The elastin-containing structures within the intima-media region encompass the elastic lamellae (EL) and internal elastic lamina (IEL) and are crucial for normal arterial function. Here, the development of a novel electrospun small-diameter vascular graft that facilitates de novo formation of a structurally appropriate elastin-containing intima-media region following implantation is described. The graft comprises a non-porous microstructure characterized by tropoelastin fibers that are embedded in a PGS matrix. After implantation in mouse abdominal aorta, the graft develops distinct cell and extracellular matrix profiles that approximate the native adventitia and intima-media by 8 weeks. Within the newly formed intima-media region there are circumferentially aligned smooth muscle cell layers that alternate with multiple EL similar to that found in the arterial wall. By 8 months, the developed adventitia region contains mature collagen fibrils and the neoartery presents a distinct IEL with thickness comparable to that in mouse abdominal aorta. It is proposed that this new class of material can generate the critically required, organized elastin needed for arterial regeneration 
650 4 |a Journal Article 
650 4 |a elastic lamellae 
650 4 |a elastin 
650 4 |a internal elastic lamina 
650 4 |a polyglycerol sebacate 
650 4 |a regenerative medicine 
650 4 |a tissue engineering 
650 4 |a tropoelastin 
650 4 |a vascular grafts 
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650 7 |a 9007-58-3  |2 NLM 
650 7 |a Collagen  |2 NLM 
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700 1 |a Mithieux, Suzanne M  |e verfasserin  |4 aut 
700 1 |a Vindin, Howard  |e verfasserin  |4 aut 
700 1 |a Wang, Yiwei  |e verfasserin  |4 aut 
700 1 |a Zhang, Miao  |e verfasserin  |4 aut 
700 1 |a Liu, Linyang  |e verfasserin  |4 aut 
700 1 |a Zbinden, Jacob  |e verfasserin  |4 aut 
700 1 |a Blum, Kevin M  |e verfasserin  |4 aut 
700 1 |a Yi, Tai  |e verfasserin  |4 aut 
700 1 |a Matsuzaki, Yuichi  |e verfasserin  |4 aut 
700 1 |a Oveissi, Farshad  |e verfasserin  |4 aut 
700 1 |a Akdemir, Reyda  |e verfasserin  |4 aut 
700 1 |a Lockley, Karen M  |e verfasserin  |4 aut 
700 1 |a Zhang, Lingyue  |e verfasserin  |4 aut 
700 1 |a Ma, Ke  |e verfasserin  |4 aut 
700 1 |a Guan, Juan  |e verfasserin  |4 aut 
700 1 |a Waterhouse, Anna  |e verfasserin  |4 aut 
700 1 |a Pham, Nguyen T H  |e verfasserin  |4 aut 
700 1 |a Hawkett, Brian S  |e verfasserin  |4 aut 
700 1 |a Shinoka, Toshiharu  |e verfasserin  |4 aut 
700 1 |a Breuer, Christopher K  |e verfasserin  |4 aut 
700 1 |a Weiss, Anthony S  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 34(2022), 47 vom: 01. Nov., Seite e2205614  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnas 
773 1 8 |g volume:34  |g year:2022  |g number:47  |g day:01  |g month:11  |g pages:e2205614 
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