A Calcium Fluoride Nanozyme for Ultrasound-Amplified and Ca2+ -Overload-Enhanced Catalytic Tumor Nanotherapy

A Calcium Fluoride Nanozyme for Ultrasound-Amplified and Ca2+ -Overload-Enhanced Catalytic Tumor Nanotherapy

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 43 vom: 22. Okt., Seite e2205680
1. Verfasser: Dong, Caihong (VerfasserIn)
Weitere Verfasser: Dai, Xinyue, Wang, Xi, Lu, Qing, Chen, Liang, Song, Xinran, Ding, Li, Huang, Hui, Feng, Wei, Chen, Yu, Chang, Meiqi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article calcium overload mitochondrial dysfunction peroxidase-mimicking activity ultrasound Reactive Oxygen Species Calcium Fluoride O3B55K4YKI Calcium SY7Q814VUP mehr... Peroxidase EC 1.11.1.7 Peroxidases EC 1.11.1.- Antioxidants
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100 1 |a Dong, Caihong  |e verfasserin  |4 aut 
245 1 2 |a A Calcium Fluoride Nanozyme for Ultrasound-Amplified and Ca2+ -Overload-Enhanced Catalytic Tumor Nanotherapy 
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520 |a The anticancer mechanism of nanozymes is dominantly associated with the capacity for generation of reactive oxygen species (ROS) caused by the valence change of metal elements. However, very little research is focused on and has achieved the exploration and development of enzyme-mimicking activities of valence-invariable metal compounds. Herein, a distinct valence-invariable calcium fluoride (CaF2 ) nanozyme with ultrasound (US)-enhanced peroxidase (POD)-mimicking activity is rationally designed and engineered for efficient calcium (Ca2+ )-overload-enhanced catalytic tumor nanotherapy, which is the first paradigm of Ca-based nanozymes for catalytic cancer treatment. The release of exogenous Ca2+ ions from CaF2 nanocrystals and deleterious ROS generation derived from US-amplified POD-mimicking properties facilitate intracellular Ca2+ accumulation and achieve Ca2+ -overload-induced mitochondrial dysfunction through introducing exogenous Ca2+ ions and regulating calcium-pumping channels of neoplastic cells. Especially, US as an exogenous energy input is capable of substantially amplifying POD-mimicking catalytic activities of CaF2 nanozyme, ultimately achieving efficient anti-neoplastic outcome on both 4T1 breast tumor and H22 hepatic carcinoma animal models. Such a discovery of enzyme-like activity of valence-invariable metal compounds can broaden the cognition scope of nanozymes and effectively serves the field of catalytic and chemoreactive nanomedicine 
650 4 |a Journal Article 
650 4 |a calcium overload 
650 4 |a mitochondrial dysfunction 
650 4 |a peroxidase-mimicking activity 
650 4 |a ultrasound 
650 7 |a Reactive Oxygen Species  |2 NLM 
650 7 |a Calcium Fluoride  |2 NLM 
650 7 |a O3B55K4YKI  |2 NLM 
650 7 |a Calcium  |2 NLM 
650 7 |a SY7Q814VUP  |2 NLM 
650 7 |a Peroxidase  |2 NLM 
650 7 |a EC 1.11.1.7  |2 NLM 
650 7 |a Peroxidases  |2 NLM 
650 7 |a EC 1.11.1.-  |2 NLM 
650 7 |a Antioxidants  |2 NLM 
700 1 |a Dai, Xinyue  |e verfasserin  |4 aut 
700 1 |a Wang, Xi  |e verfasserin  |4 aut 
700 1 |a Lu, Qing  |e verfasserin  |4 aut 
700 1 |a Chen, Liang  |e verfasserin  |4 aut 
700 1 |a Song, Xinran  |e verfasserin  |4 aut 
700 1 |a Ding, Li  |e verfasserin  |4 aut 
700 1 |a Huang, Hui  |e verfasserin  |4 aut 
700 1 |a Feng, Wei  |e verfasserin  |4 aut 
700 1 |a Chen, Yu  |e verfasserin  |4 aut 
700 1 |a Chang, Meiqi  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 34(2022), 43 vom: 22. Okt., Seite e2205680  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:34  |g year:2022  |g number:43  |g day:22  |g month:10  |g pages:e2205680 
856 4 0 |u http://dx.doi.org/10.1002/adma.202205680  |3 Volltext 
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