Osa-miR160a confers broad-spectrum resistance to fungal and bacterial pathogens in rice

Osa-miR160a confers broad-spectrum resistance to fungal and bacterial pathogens in rice

© 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 236(2022), 6 vom: 18. Dez., Seite 2216-2232
1. Verfasser: Feng, Qin (VerfasserIn)
Weitere Verfasser: Wang, He, Yang, Xue-Mei, Hu, Zhang-Wei, Zhou, Xin-Hui, Xiang, Ling, Xiong, Xiao-Yu, He, Xiao-Rong, Zhu, Yong, Li, Guo-Bang, Zhao, Jing-Hao, Ji, Yun-Peng, Hu, Xiao-Hong, Pu, Mei, Zhou, Shi-Xin, Zhao, Zhi-Xue, Zhang, Ji-Wei, Huang, Yan-Yan, Fan, Jing, Wang, Wen-Ming, Li, Yan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't ARFs WRKY45 bacterial leaf blight miR160a rice blast rice sheath blight Plant Proteins
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520 |a © 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation. 
520 |a Rice production is threatened by multiple pathogens. Breeding cultivars with broad-spectrum disease resistance is necessary to maintain and improve crop production. Previously we found that overexpression of miR160a enhanced rice blast disease resistance. However, it is unclear whether miR160a also regulates resistance against other pathogens, and what the downstream signaling pathways are. Here, we demonstrate that miR160a positively regulates broad-spectrum resistance against the causative agents of blast, leaf blight and sheath blight in rice. Mutations of miR160a-targeted Auxin Response Factors result in different alteration of resistance conferred by miR160a. miR160a enhances disease resistance partially by suppressing ARF8, as mutation of ARF8 in MIM160 background partially restores the compromised resistance resulting from MIM160. ARF8 protein binds directly to the promoter and suppresses the expression of WRKY45, which acts as a positive regulator of rice immunity. Mutation of WRKY45 compromises the enhanced blast resistance and bacterial leaf blight resistance conferred by arf8 mutant. Overall, our results reveal that a microRNA coordinates rice broad-spectrum disease resistance by suppressing multiple target genes that play different roles in disease resistance, and uncover a new regulatory pathway mediated by the miR160a-ARF8 module. These findings provide new resources to potentially improve disease resistance for breeding in rice 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a ARFs 
650 4 |a WRKY45 
650 4 |a bacterial leaf blight 
650 4 |a miR160a 
650 4 |a rice blast 
650 4 |a rice sheath blight 
650 7 |a Plant Proteins  |2 NLM 
700 1 |a Wang, He  |e verfasserin  |4 aut 
700 1 |a Yang, Xue-Mei  |e verfasserin  |4 aut 
700 1 |a Hu, Zhang-Wei  |e verfasserin  |4 aut 
700 1 |a Zhou, Xin-Hui  |e verfasserin  |4 aut 
700 1 |a Xiang, Ling  |e verfasserin  |4 aut 
700 1 |a Xiong, Xiao-Yu  |e verfasserin  |4 aut 
700 1 |a He, Xiao-Rong  |e verfasserin  |4 aut 
700 1 |a Zhu, Yong  |e verfasserin  |4 aut 
700 1 |a Li, Guo-Bang  |e verfasserin  |4 aut 
700 1 |a Zhao, Jing-Hao  |e verfasserin  |4 aut 
700 1 |a Ji, Yun-Peng  |e verfasserin  |4 aut 
700 1 |a Hu, Xiao-Hong  |e verfasserin  |4 aut 
700 1 |a Pu, Mei  |e verfasserin  |4 aut 
700 1 |a Zhou, Shi-Xin  |e verfasserin  |4 aut 
700 1 |a Zhao, Zhi-Xue  |e verfasserin  |4 aut 
700 1 |a Zhang, Ji-Wei  |e verfasserin  |4 aut 
700 1 |a Huang, Yan-Yan  |e verfasserin  |4 aut 
700 1 |a Fan, Jing  |e verfasserin  |4 aut 
700 1 |a Wang, Wen-Ming  |e verfasserin  |4 aut 
700 1 |a Li, Yan  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t The New phytologist  |d 1979  |g 236(2022), 6 vom: 18. Dez., Seite 2216-2232  |w (DE-627)NLM09818248X  |x 1469-8137  |7 nnns 
773 1 8 |g volume:236  |g year:2022  |g number:6  |g day:18  |g month:12  |g pages:2216-2232 
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