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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.5308
|2 doi
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|a pubmed25n1152.xml
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|a (DE-627)NLM345746740
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|a (NLM)36057451
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|a eng
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|a Ablo, Evrard
|e verfasserin
|4 aut
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|a Synthesis and characterization of novel conformers of (E)-2-(3-nitro-H-imidazo[1,2-a]pyridin-2-ylthio)-N'-benzylideneacetohydrazide derivatives
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|c 2022
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|a Text
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|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 08.11.2022
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|a Date Revised 04.01.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 John Wiley & Sons Ltd.
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|a Eighteen new N-acylhydrazones (9a-r) containing the imidazo[1,2-a]pyridine scaffold were synthesized through a seven steps reaction sequence, ending with a condensation of 2-(3-nitro-H-imidazo[1,2-a]pyridin-2-ylthio)acetohydrazide with various benzaldehyde derivatives (8a-r). All synthesized compounds were characterized by 1D NMR (1 H and 13 C NMR) and 2D NMR (NOESY) spectroscopic analyses and high-resolution mass spectrometry (HRMS). The analysis of 1 H NMR data performed at room temperature in deuterated dimethylsulfoxide (DMSO-d6 ) revealed the presence of (E)-2-(3-nitro-H-imidazo[1,2-a]pyridin-2-ylthio)-N'-benzylideneacetohydrazide (9a-r) as a mixture of two conformers, namely, syn-periplanar E (sp E) and anti-periplanar E (ap E). For all N-acylhydrazones that were synthesized, the sp E conformer was found to be the major form except in the case of hydrazone derived from o-hydroxybenzaldehyde
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|a Journal Article
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|a 13C
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|a 1H
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|a 2D-NOESY NMR in DMSO-d6
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|a N-acyl-hydrazones
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|a benzaldehydes
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|a conformational analysis
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|a hydrazide-hydrazones
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|a imidazo[1,2-a]pyridine
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|a Hydrazones
|2 NLM
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|a Dimethyl Sulfoxide
|2 NLM
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|a YOW8V9698H
|2 NLM
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|a Coulibaly, Souleymane
|e verfasserin
|4 aut
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|a Coulibali, Siomenan
|e verfasserin
|4 aut
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|a Signo, Kouassi
|e verfasserin
|4 aut
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|a Achi, Patrick-Armand
|e verfasserin
|4 aut
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|a Giraud, Nicolas
|e verfasserin
|4 aut
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|a Bertho, Gildas
|e verfasserin
|4 aut
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 60(2022), 12 vom: 01. Dez., Seite 1157-1170
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnas
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|g volume:60
|g year:2022
|g number:12
|g day:01
|g month:12
|g pages:1157-1170
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|u http://dx.doi.org/10.1002/mrc.5308
|3 Volltext
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