The tomato resistance gene Bs4 suppresses leaf watersoaking phenotypes induced by AvrHah1, a transcription activator-like effector from tomato-pathogenic xanthomonads

The tomato resistance gene Bs4 suppresses leaf watersoaking phenotypes induced by AvrHah1, a transcription activator-like effector from tomato-pathogenic xanthomonads

© 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 236(2022), 5 vom: 15. Dez., Seite 1856-1870
1. Verfasser: Schenstnyi, Kyrylo (VerfasserIn)
Weitere Verfasser: Strauß, Annett, Dressel, Angela, Morbitzer, Robert, Wunderlich, Markus, Andrade, Ana Gabriela, Phan, Trang-Thi-Thu, Aguilera, Paloma de Los Angeles, Brancato, Caterina, Berendzen, Kenneth Wayne, Lahaye, Thomas
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Xanthomonas AvrHah1 basic helix-loop-helix (bHLH) domain transcription factor nucleotide-binding leucine-rich repeat (NLR) protein pectate lyase pectinesterase susceptibility (S) gene transcription-activator-like effector (TALE) mehr... Transcription Activator-Like Effectors Bacterial Proteins Plant Proteins
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245 1 4 |a The tomato resistance gene Bs4 suppresses leaf watersoaking phenotypes induced by AvrHah1, a transcription activator-like effector from tomato-pathogenic xanthomonads 
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520 |a The Xanthomonas transcription activator-like effector (TALE) protein AvrBs3 transcriptionally activates the executor-type resistance (R) gene Bs3 from pepper (Capsicum annuum), thereby triggering a hypersensitive cell death reaction (HR). AvrBs3 also triggers an HR in tomato (Solanum lycopersicum) upon recognition by the nucleotide-binding leucine-rich repeat (NLR) R protein Bs4. Whether the executor-type R protein Bs3 and the NLR-type R protein Bs4 use common or distinct signalling components to trigger an HR remains unclear. CRISPR/Cas9-mutagenesis revealed, that the immune signalling node EDS1 is required for Bs4- but not for Bs3-dependent HR, suggesting that NLR- and executor-type R proteins trigger an HR via distinct signalling pathways. CRISPR/Cas9-mutagenesis also revealed that tomato Bs4 suppresses the virulence function of both TALEs, the HR-inducing AvrBs3 protein and of AvrHah1, a TALE that does not trigger an HR in tomato. Analysis of AvrBs3- and AvrHah1-induced host transcripts and disease phenotypes in CRISPR/Cas9-induced bs4 mutant plants indicates that both TALEs target orthologous transcription factor genes to promote disease in tomato and pepper host plants. Our studies display that tomato mutants lacking the TALE-sensing Bs4 protein provide a novel platform to either uncover TALE-induced disease phenotypes or genetically dissect components of executor-triggered HR 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Xanthomonas 
650 4 |a AvrHah1 
650 4 |a basic helix-loop-helix (bHLH) domain transcription factor 
650 4 |a nucleotide-binding leucine-rich repeat (NLR) protein 
650 4 |a pectate lyase 
650 4 |a pectinesterase 
650 4 |a susceptibility (S) gene 
650 4 |a transcription-activator-like effector (TALE) 
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650 7 |a Plant Proteins  |2 NLM 
700 1 |a Strauß, Annett  |e verfasserin  |4 aut 
700 1 |a Dressel, Angela  |e verfasserin  |4 aut 
700 1 |a Morbitzer, Robert  |e verfasserin  |4 aut 
700 1 |a Wunderlich, Markus  |e verfasserin  |4 aut 
700 1 |a Andrade, Ana Gabriela  |e verfasserin  |4 aut 
700 1 |a Phan, Trang-Thi-Thu  |e verfasserin  |4 aut 
700 1 |a Aguilera, Paloma de Los Angeles  |e verfasserin  |4 aut 
700 1 |a Brancato, Caterina  |e verfasserin  |4 aut 
700 1 |a Berendzen, Kenneth Wayne  |e verfasserin  |4 aut 
700 1 |a Lahaye, Thomas  |e verfasserin  |4 aut 
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