An Enzyme-Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis-Based Synergistic Cancer Therapy

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 43 vom: 01. Okt., Seite e2204733
1. Verfasser:	Xu, Yuzhi (VerfasserIn)
Weitere Verfasser:	Liu, Si-Yang, Zeng, Leli, Ma, Hansu, Zhang, Yanfei, Yang, Huihui, Liu, Yuchen, Fang, Shuo, Zhao, Jing, Xu, Yunsheng, Ashby, Charles R Jr, He, Yulong, Dai, Zong, Pan, Yihang
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article coordination polymers cuproptosis glucose oxidase photodynamic therapy starvation therapy Copper 789U1901C5 Glucose IY9XDZ35W2 mehr... Glucose Oxidase EC 1.1.3.4 Glutathione GAN16C9B8O Hydrogen Peroxide BBX060AN9V Mitochondrial Proteins Polymers

Beschreibung
Zusammenfassung:	© 2022 Wiley-VCH GmbH. Cuproptosis, a newly identified form of regulated cell death that is copper-dependent, offers great opportunities for exploring the use of copper-based nanomaterials inducing cuproptosis for cancer treatment. Here, a glucose oxidase (GOx)-engineered nonporous copper(I) 1,2,4-triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx[Cu(tz)], for starvation-augmented cuproptosis and photodynamic synergistic therapy is developed. Importantly, the catalytic activity of GOx is shielded in the nonporous scaffold but can be "turned on" for efficient glucose depletion only upon glutathione (GSH) stimulation in cancer cells, thereby proceeding cancer starvation therapy. The depletion of glucose and GSH sensitizes cancer cells to the GOx@[Cu(tz)]-mediated cuproptosis, producing aggregation of lipoylated mitochondrial proteins, the target of copper-induced toxicity. The increased intracellular hydrogen peroxide (H2 O2 ) levels, due to the oxidation of glucose, activates the type I photodynamic therapy (PDT) efficacy of GOx@[Cu(tz)]. The in vivo experimental results indicate that GOx@[Cu(tz)] produces negligible systemic toxicity and inhibits tumor growth by 92.4% in athymic mice bearing 5637 bladder tumors. This is thought to be the first report of a cupreous nanomaterial capable of inducing cuproptosis and cuproptosis-based synergistic therapy in bladder cancer, which should invigorate studies pursuing rational design of efficacious cancer therapy strategies based on cuproptosis
Beschreibung:	Date Completed 15.02.2023 Date Revised 29.03.2023 published: Print-Electronic ErratumIn: Adv Mater. 2023 Mar;35(13):e2300773. - PMID 36987684 Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202204733