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20231226025133.0 |
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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2022.109101
|2 doi
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|a pubmed24n1151.xml
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|a (DE-627)NLM345474171
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|a (NLM)36029976
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|a (PII)S1521-6616(22)00182-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Yang, Gui
|e verfasserin
|4 aut
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| 245 |
1 |
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|a 5-HT is associated with the dysfunction of regulating T cells in patients with allergic rhinitis
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 20.09.2022
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|a Date Revised 11.11.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2022 Elsevier Inc. All rights reserved.
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|a The dysfunction of regulating T lymphocytes (Treg) is associated with the pathogenesis of many diseases. 5-hydroxytryptamine (5-HT) is capable of interacting with immune cells. The objective of the present study is to shed light on the role of 5-HT in regulating Treg activities. Blood samples were collected from patients with perennial allergic rhinitis (AR). Tregs were isolated from blood samples by magnetic cell sorting. The levels of 5-HT and other cytokines were determined by enzyme-linked immunosorbent assay. The results showed that serum 5-HT levels in patients with AR were higher than in healthy control (HC) subjects. A positive correlation was identified in the data between 5-HT concentrations and AR-related cytokine concentrations in the serum. A negative correlation was found between serum levels of 5-HT and the peripheral frequency of Treg. Exposure to 5-HT enhanced the expression of IL-6 and IL-21 in dendritic cells (DC). Co-culture of 5-HT-primed DCs with Tregs led to the conversion of Th17 cells. STAT3 blockade efficiently abolished the 5-HT-associated conversion of Th17 cells from Tregs. In summary, patients with AR exhibited higher serum concentrations of 5-HT. 5-HT-primed DCs could convert Tregs to Th17 cells
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 5-HT
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|a Allergy
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|a Dendritic cells
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|a Nose
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|a Regulatory T cells
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|a Cytokines
|2 NLM
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|a Interleukin-6
|2 NLM
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|a Serotonin
|2 NLM
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| 650 |
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|a 333DO1RDJY
|2 NLM
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| 700 |
1 |
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|a Wu, Gaohui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Wenkai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guan, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Geng, Xiaorui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Jiangqi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Zhiqiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Liteng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Qinmiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Xianhai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Pingchang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 243(2022) vom: 31. Okt., Seite 109101
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:243
|g year:2022
|g day:31
|g month:10
|g pages:109101
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2022.109101
|3 Volltext
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|a GBV_ILN_350
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|a AR
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|d 243
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|h 109101
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