Tumor Selective Metabolic Reprogramming as a Prospective PD-L1 Depression Strategy to Reactivate Immunotherapy

Tumor Selective Metabolic Reprogramming as a Prospective PD-L1 Depression Strategy to Reactivate Immunotherapy

© 2022 Wiley-VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 41 vom: 01. Okt., Seite e2206121
Auteur principal: Liu, Yu (Auteur)
Autres auteurs: Zhou, Zaigang, Hou, Jiting, Xiong, Wei, Kim, Heejeong, Chen, Jiashe, Zheng, Chunjuan, Jiang, Xin, Yoon, Juyoung, Shen, Jianliang
Format: Article en ligne
Langue:English
Publié: 2022
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article immunotherapy mitochondria photodynamic therapy programmed death ligand-1 tumor targeting Albumins Antibodies, Monoclonal B7-H1 Antigen Carbocyanines plus... Immunologic Factors Ligands Programmed Cell Death 1 Receptor heptamethine cyanine dye Oxygen S88TT14065
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500 |a Date Completed 17.10.2022 
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520 |a Currently, the role of the lysosome, endoplasmic reticulum, or dictyosome in the transcription and translation of programmed cell death ligand 1 (PD-L1) is well revealed, but the role and function of mitochondria in the PD-L1 expression in tumors is still not fully researched, making it hard to offer a novel PD-L1 regulation strategy. In this research, it is newly revealed that mitochondria oxidative phosphorylation (OXPHOS) depression can be used as an effective PD-L1 down-regulation method. To offer an ideal and high-effective tumor mitochondria-targeted OXPHOS depression nanosystem, IR-LND is prepared by conjugating mitochondria-targeted heptamethine cyanine dye IR-68 with mitochondrial complexes I and II depression agent lonidamine (LND), which then further self-assembled with albumin (Alb) to form IR-LNDAlb nanoparticles. By doing this, PD-L1 expression in tumors is selectively and effectively depressed by IR-LND@Alb nanoparticles. As expected, the anti-tumor efficacy of such a PD-L1 depression strategy is superior to conventional anti-PD-L1 monoclonal antibodies. Interestingly, IR-LND can also be served as a novel ideal promising photodynamic therapy (PDT) drug with self-oxygen and self-PD-L1 regulation capacity. All in all, this tumor-selective metabolic reprogramming platform to reactivate immunotherapy and sensitize for PDT effect, would open a new window for mitochondrial immunotherapy for cancer patients 
650 4 |a Journal Article 
650 4 |a immunotherapy 
650 4 |a mitochondria 
650 4 |a photodynamic therapy 
650 4 |a programmed death ligand-1 
650 4 |a tumor targeting 
650 7 |a Albumins  |2 NLM 
650 7 |a Antibodies, Monoclonal  |2 NLM 
650 7 |a B7-H1 Antigen  |2 NLM 
650 7 |a Carbocyanines  |2 NLM 
650 7 |a Immunologic Factors  |2 NLM 
650 7 |a Ligands  |2 NLM 
650 7 |a Programmed Cell Death 1 Receptor  |2 NLM 
650 7 |a heptamethine cyanine dye  |2 NLM 
650 7 |a Oxygen  |2 NLM 
650 7 |a S88TT14065  |2 NLM 
700 1 |a Zhou, Zaigang  |e verfasserin  |4 aut 
700 1 |a Hou, Jiting  |e verfasserin  |4 aut 
700 1 |a Xiong, Wei  |e verfasserin  |4 aut 
700 1 |a Kim, Heejeong  |e verfasserin  |4 aut 
700 1 |a Chen, Jiashe  |e verfasserin  |4 aut 
700 1 |a Zheng, Chunjuan  |e verfasserin  |4 aut 
700 1 |a Jiang, Xin  |e verfasserin  |4 aut 
700 1 |a Yoon, Juyoung  |e verfasserin  |4 aut 
700 1 |a Shen, Jianliang  |e verfasserin  |4 aut 
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773 1 8 |g volume:34  |g year:2022  |g number:41  |g day:01  |g month:10  |g pages:e2206121 
856 4 0 |u http://dx.doi.org/10.1002/adma.202206121  |3 Volltext 
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