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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c01199
|2 doi
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|a pubmed24n1149.xml
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|a (DE-627)NLM344946800
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|a (NLM)35976036
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Ishimoto, Arisa
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Drug-Loaded Nanocarriers Composed of Cholesteryl Oleate Crystal Cores and Multiple-Nanosheet Shells of γ-Cyclodextrin Inclusion Complex Crystals
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 31.08.2022
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|a Date Revised 13.10.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In this study, we prepared drug-loaded nanocarriers made of cholesteryl oleate (ChO) and γ-cyclodextrin (γ-CD). A nanosuspension (nanosuspension-I, NS-I) containing nanoparticles with a mean size of approximately 170 nm was obtained through the solvent-diffusion method using ethanol. A second nanosuspension (nanosuspension-II, NS-II), which was prepared by freeze-drying and redispersion of NS-I, exhibited an increased particle size of approximately 210 nm. Cryogenic transmission electron microscopy (cryo-TEM) and atomic force microscopy (AFM) force-distance curves indicated that the nanoparticles in NS-I were oblong and soft. However, those in NS-II were angular and stiff, and, interestingly, multiple nanosheets covered the solid-liquid interface. Synchrotron wide-angle X-ray diffraction (WAXD) analysis of NS-II indicated that the nanoparticles in it had a core-shell structure, where the ChO crystal in the inner core was covered by multiple nanosheets of ChO/γ-CD inclusion complex crystals. The X-ray peak analysis suggested that the γ-CD columns of the nanosheets were vertically stacked onto the ChO crystal interface. It was found that the nanosheets on the nanoparticle interface were formed during the freezing process. A model drug carbamazepine (CBZ) was loaded into the ChO/γ-CD nanoparticles by pre-dissolving CBZ in ethanol during the solvent-diffusion process. Cryo-TEM, 1H NMR, ζ-potentials, and synchrotron WAXD indicated that CBZ was unexpectedly loaded into the shell as a CBZ/γ-CD inclusion complex crystalline nanosheet. The specific nanosheet structure, where ChO and CBZ coexisted in the same crystal of γ-CD, could achieve CBZ loading in the nanoparticles. ChO/γ-CD nanoparticles with the unique core-shell structure are expected to perform as practical carriers for drug delivery
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Cholesterol Esters
|2 NLM
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|a Pharmaceutical Preparations
|2 NLM
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|a Solvents
|2 NLM
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|a gamma-Cyclodextrins
|2 NLM
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|a cholesteryl oleate
|2 NLM
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|a 3DPK9KFN2M
|2 NLM
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| 650 |
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|a Ethanol
|2 NLM
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| 650 |
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|a 3K9958V90M
|2 NLM
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| 700 |
1 |
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|a Sasako, Hiroshi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Omori, Masaki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Higashi, Kenjirou
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ueda, Keisuke
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Koyama, Kazuo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Moribe, Kunikazu
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 38(2022), 34 vom: 30. Aug., Seite 10454-10464
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:38
|g year:2022
|g number:34
|g day:30
|g month:08
|g pages:10454-10464
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|u http://dx.doi.org/10.1021/acs.langmuir.2c01199
|3 Volltext
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|d 38
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|c 08
|h 10454-10464
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