CSF from a puppy with a cerebral vascular hamartoma

© 2022 American Society for Veterinary Clinical Pathology.

Bibliographische Detailangaben
Veröffentlicht in:Veterinary clinical pathology. - 1975. - 52(2023), 1 vom: 16. März, Seite 97-101
1. Verfasser: Williams, Marjorie J (VerfasserIn)
Weitere Verfasser: Baughman, Brittany S, Shores, Andy, Gibson, Ryan M B, Beasley, Michaela J, Morgan, Timothy W, Williams, Matthew L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Veterinary clinical pathology
Schlagworte:Case Reports CSF bilirubin crystals hematoidin hemorrhage
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520 |a A 9-week-old puppy with refractory seizures and a dome-shaped head presented to the Mississippi State College of Veterinary Medicine Specialty Center for suspected hydrocephalus. Computerized tomography (CT) findings included transtentorial herniation and an intra-axial mass with dystrophic mineralization. Cerebrospinal fluid analysis revealed an increased nucleated cell count of 1100/μl (RI < 5/μl), erythrocyte count of 2.2 × 106 /μl, and markedly increased microprotein of 1939 mg/dl (RI < 30 mg/dl). On cytologic examination of the CSF, numerous erythrophagocytic, and hemosiderin-laden macrophages were observed, which indicated chronic active hemorrhage. Many neutrophils, macrophages, and lymphocytes that contained numerous intracytoplasmic, pleomorphic, bright yellow crystals were observed. Considering the ongoing hemorrhage, the crystals were presumed to be hematoidin. A biopsy with histopathology was performed on the intra-axial mass, and the results were consistent with a vascular hamartoma. We speculate that the formation of these crystals was related to the ongoing hemorrhage associated with the vascular hamartoma. Identification of these crystals may be useful to aid in the identification of chronic hemorrhage associated with vascular malformations or lesions within the central nervous system 
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700 1 |a Baughman, Brittany S  |e verfasserin  |4 aut 
700 1 |a Shores, Andy  |e verfasserin  |4 aut 
700 1 |a Gibson, Ryan M B  |e verfasserin  |4 aut 
700 1 |a Beasley, Michaela J  |e verfasserin  |4 aut 
700 1 |a Morgan, Timothy W  |e verfasserin  |4 aut 
700 1 |a Williams, Matthew L  |e verfasserin  |4 aut 
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