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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c01758
|2 doi
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|a pubmed24n1149.xml
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|a (NLM)35960930
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Wei, Jirui
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Hybrid Hydrogels from Nongelling Polymers Using a Fibrous Peptide Hydrogelator at Low Concentrations
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 24.08.2022
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|a Date Revised 29.08.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Nature-made hydrogels typically combine a wide range of multiscale fibers into biological composite networks, which offer an adaptive property. Inspired by nature, we report a facile approach to construct hybrid hydrogels from a range of natural or commercially available synthetic nongelling polymers (e.g., poly(ethylene glycol), poly(acrylic acid), carboxylated cellulose nanocrystal, and sodium alginate) at a concentration as low as 0.53 wt % using a nonionic fibrous peptide hydrogelator. Through simply mixing the peptide hydrogelator with a polymer aqueous solution, stable hybrid hydrogels can be formed with the concentration of hydrogelator at ∼0.05 wt %. The gel strength of the resulting hydrogels can be effectively modulated by the concentration, molecular weight, and terminal group of the polymer. We further demonstrate that the molecular interactions between the peptide hydrogelator and the polymer are very crucial for the formation of hybrid hydrogel, which synergically induce the gelation at considerably low concentrations. A peptide hydrogelator can be easily obtained by aminolysis of alkyl-oilgo(γ-benzyl-l-glutamate) samples. Live/Dead assays indicate low cytotoxicity of the hybrid hydrogel toward HeLa cells. Combining the low-cost, scalable synthesis, and biocompatibility, the prepared peptide hydrogelator presents a potential candidate to expand the scope of polymer hydrogels for biomedical applications and also shows considerable commercial significance
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Hydrogels
|2 NLM
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|a Peptides
|2 NLM
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|a Polymers
|2 NLM
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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|a 3WJQ0SDW1A
|2 NLM
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| 700 |
1 |
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|a Lin, Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Xiaohui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Jing
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 38(2022), 33 vom: 23. Aug., Seite 10305-10312
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:38
|g year:2022
|g number:33
|g day:23
|g month:08
|g pages:10305-10312
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|u http://dx.doi.org/10.1021/acs.langmuir.2c01758
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