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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erac322
|2 doi
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|a pubmed25n1149.xml
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|a (DE-627)NLM344786471
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|a (NLM)35959860
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Mencia, Regina
|e verfasserin
|4 aut
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|a Keeping up with the miRNAs
|b current paradigms of the biogenesis pathway
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.04.2023
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|a Date Revised 04.06.2023
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a For many years we have studied the processes involved in producing miRNAs in plants and the numerous differences from their metazoan counterpart. A well-defined catalytic process, mostly carried out by the RNase III enzyme DICER-LIKE1 (DCL1), it was identified early after the discovery of RNAi and was followed by the isolation of a plethora of miRNA biogenesis cofactors. The production of miRNAs, which later are loaded in ARGONAUTE (AGO) proteins to perform their RNA silencing functions both within the cell and non-cell autonomously, appears to be a highly regulated and dynamic process. Many regulatory events during miRNA biogenesis require the action of specific proteins. However, in recent years, many post-transcriptional modifications, structural features, and coupling with other cellular processing emerged as critical elements controlling the production of miRNA and, thus, a plant's physiology. This review discusses new evidence that has changed the way we understand how miRNAs are produced in plants. We also provide an updated view of the miRNA biogenesis pathways, focusing on the gaps in our knowledge and the most compelling questions that remain open
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|a Review
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a D-bodies
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|a DCL1
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|a HYL1
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|a RNA structure and modifications
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|a gene silencing
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|a miRNA
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|a miRNA biogenesis
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|a pri-miRNA processing
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|a small RNAs
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|a Arabidopsis Proteins
|2 NLM
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|a MicroRNAs
|2 NLM
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|a RNA-Binding Proteins
|2 NLM
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|a Gonzalo, Lucía
|e verfasserin
|4 aut
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|a Tossolini, Ileana
|e verfasserin
|4 aut
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| 700 |
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|a Manavella, Pablo A
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 74(2023), 7 vom: 09. Apr., Seite 2213-2227
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnas
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| 773 |
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|g volume:74
|g year:2023
|g number:7
|g day:09
|g month:04
|g pages:2213-2227
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|u http://dx.doi.org/10.1093/jxb/erac322
|3 Volltext
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