Outcomes at discharge of preterm infants born <34 weeks' gestation

Outcomes at discharge of preterm infants born <34 weeks' gestation

Objective: To investigate the incidence and trend of short-term outcomes among preterm infants born <34 weeks' gestation. Methods: A secondary analysis of data from the standardized database established by a multicenter cluster-randomized controlled study "reduction of infection in neon...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 60(2022), 8 vom: 02. Aug., Seite 774-780
1. Verfasser: Luo, N X (VerfasserIn)
Weitere Verfasser: Jiang, S Y, Cao, S J, Li, J Y, Han, Q, Zhou, M M, Li, J Z, Guo, G Y, Liu, Z M, Yang, C, Ji, B Q, Zhang, Z F, Huang, J, Yuan, D D, Pan, J Y, Shi, X F, Hu, S, Lin, Q, Zhao, C G, Yan, Y, Wang, Q F, Wei, Q, Kan, J Q, Gao, C Q, Liu, S Y, Jiang, X G, Liu, H Q, Sun, J, Du, L, He, Li, Reduction of Infection in Chinese Neonatal Intensive Care Units Using the Evidence-based Practice for Improving Quality
Format: Online-Aufsatz
Sprache:Chinese
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Zhonghua er ke za zhi = Chinese journal of pediatrics
Schlagworte:Journal Article Multicenter Study Randomized Controlled Trial
LEADER 01000naa a22002652 4500
001 NLM344417557
003 DE-627
005 20231226022728.0
007 cr uuu---uuuuu
008 231226s2022 xx |||||o 00| ||chi c
024 7 |a 10.3760/cma.j.cn112140-20220103-00002  |2 doi 
028 5 2 |a pubmed24n1148.xml 
035 |a (DE-627)NLM344417557 
035 |a (NLM)35922187 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a chi 
100 1 |a Luo, N X  |e verfasserin  |4 aut 
245 1 0 |a Outcomes at discharge of preterm infants born <34 weeks' gestation 
264 1 |c 2022 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 05.08.2022 
500 |a Date Revised 08.08.2022 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a Objective: To investigate the incidence and trend of short-term outcomes among preterm infants born <34 weeks' gestation. Methods: A secondary analysis of data from the standardized database established by a multicenter cluster-randomized controlled study "reduction of infection in neonatal intensive care units (NICU) using the evidence-based practice for improving quality (REIN-EPIQ) study". This study was conducted in 25 tertiary NICU. A total of 27 192 infants with gestational age <34 weeks at birth and admitted to NICU within the first 7 days of life from May 2015 to April 2018 were enrolled. Infants with severe congenital malformation were excluded. Descriptive analyses were used to describe the mortality and major morbidities of preterm infants by gestational age groups and different admission year groups. Cochran-Armitage test and Jonckheere-Terpstra test were used to analyze the trend of incidences of mortality and morbidities in 3 study-years. Multiple Logistic regression model was constructed to analyze the differences of outcomes in 3 study-years adjusting for confounders. Results: A total of 27 192 preterm infants were enrolled with gestational age of (31.3±2.0) weeks at birth and weight of (1 617±415) g at birth. Overall, 9.5% (2 594/27 192) of infants were discharged against medical advice, and the overall mortality rate was 10.7% (2 907/27 192). Mortality for infants who received complete care was 4.7% (1 147/24 598), and mortality or any major morbidity was 26.2% (6 452/24 598). The incidences of moderate to severe bronchopulmonary dysplasia, sepsis, severe intraventricular hemorrhage or periventricular leukomalacia, proven necrotizing enterocolitis, and severe retinopathy of prematurity were 16.0% (4 342/27 192), 11.9% (3 225/27 192), 6.8% (1 641/24 206), 3.6% (939/25 762) and 1.5% (214/13 868), respectively. There was a decreasing of the overall mortality (P<0.001) during the 3 years. Also, the incidences for sepsis and severe retinopathy of prematurity both decreased (both P<0.001). However, there were no significant differences in the major morbidity in preterm infants who received complete care during the 3-year study period (P=0.230). After adjusting for confounders, infants admitted during the third study year showed significantly lower risk of overall mortality (adjust OR=0.62, 95%CI 0.55-0.69, P<0.001), mortality or major morbidity, moderate to severe bronchopulmonary dysplasia, sepsis and severe retinopathy of prematurity, compared to those admitted in the first study year (all P<0.05). Conclusions: From 2015 to 2018, the mortality and major morbidities among preterm infants in Chinese NICU decreased, but there is still space for further efforts. Further targeted quality improvement is needed to improve the overall outcome of preterm infants 
650 4 |a Journal Article 
650 4 |a Multicenter Study 
650 4 |a Randomized Controlled Trial 
700 1 |a Jiang, S Y  |e verfasserin  |4 aut 
700 1 |a Cao, S J  |e verfasserin  |4 aut 
700 1 |a Li, J Y  |e verfasserin  |4 aut 
700 1 |a Han, Q  |e verfasserin  |4 aut 
700 1 |a Zhou, M M  |e verfasserin  |4 aut 
700 1 |a Li, J Z  |e verfasserin  |4 aut 
700 1 |a Guo, G Y  |e verfasserin  |4 aut 
700 1 |a Liu, Z M  |e verfasserin  |4 aut 
700 1 |a Yang, C  |e verfasserin  |4 aut 
700 1 |a Ji, B Q  |e verfasserin  |4 aut 
700 1 |a Zhang, Z F  |e verfasserin  |4 aut 
700 1 |a Huang, J  |e verfasserin  |4 aut 
700 1 |a Yuan, D D  |e verfasserin  |4 aut 
700 1 |a Pan, J Y  |e verfasserin  |4 aut 
700 1 |a Shi, X F  |e verfasserin  |4 aut 
700 1 |a Hu, S  |e verfasserin  |4 aut 
700 1 |a Lin, Q  |e verfasserin  |4 aut 
700 1 |a Zhao, C G  |e verfasserin  |4 aut 
700 1 |a Yan, Y  |e verfasserin  |4 aut 
700 1 |a Wang, Q F  |e verfasserin  |4 aut 
700 1 |a Wei, Q  |e verfasserin  |4 aut 
700 1 |a Kan, J Q  |e verfasserin  |4 aut 
700 1 |a Gao, C Q  |e verfasserin  |4 aut 
700 1 |a Liu, S Y  |e verfasserin  |4 aut 
700 1 |a Jiang, X G  |e verfasserin  |4 aut 
700 1 |a Liu, H Q  |e verfasserin  |4 aut 
700 1 |a Sun, J  |e verfasserin  |4 aut 
700 1 |a Du, L  |e verfasserin  |4 aut 
700 1 |a He, Li  |e verfasserin  |4 aut 
700 0 |a Reduction of Infection in Chinese Neonatal Intensive Care Units Using the Evidence-based Practice for Improving Quality  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Zhonghua er ke za zhi = Chinese journal of pediatrics  |d 1960  |g 60(2022), 8 vom: 02. Aug., Seite 774-780  |w (DE-627)NLM136249191  |x 0578-1310  |7 nnns 
773 1 8 |g volume:60  |g year:2022  |g number:8  |g day:02  |g month:08  |g pages:774-780 
856 4 0 |u http://dx.doi.org/10.3760/cma.j.cn112140-20220103-00002  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_11 
912 |a GBV_ILN_20 
912 |a GBV_ILN_22 
912 |a GBV_ILN_24 
912 |a GBV_ILN_31 
912 |a GBV_ILN_39 
912 |a GBV_ILN_40 
912 |a GBV_ILN_50 
912 |a GBV_ILN_61 
912 |a GBV_ILN_65 
912 |a GBV_ILN_69 
912 |a GBV_ILN_70 
912 |a GBV_ILN_72 
912 |a GBV_ILN_120 
912 |a GBV_ILN_130 
912 |a GBV_ILN_227 
912 |a GBV_ILN_244 
912 |a GBV_ILN_285 
912 |a GBV_ILN_294 
912 |a GBV_ILN_350 
912 |a GBV_ILN_665 
912 |a GBV_ILN_813 
951 |a AR 
952 |d 60  |j 2022  |e 8  |b 02  |c 08  |h 774-780