Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization

Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 37 vom: 15. Sept., Seite e2202625
1. Verfasser: Yang, Cuihong (VerfasserIn)
Weitere Verfasser: Mu, Ganen, Zhang, Ying, Gao, Yang, Zhang, Wenxue, Liu, Jinjian, Zhang, Wenwen, Li, Paiyun, Yang, Lijun, Yang, Zhimou, Gao, Jie, Liu, Jianfeng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article nitric oxide radiosensitization self-assembling peptides supramolecular hydrogels vessel normalization Radiation-Sensitizing Agents Nitric Oxide 31C4KY9ESH Oxygen S88TT14065
LEADER 01000naa a22002652 4500
001 NLM34425707X
003 DE-627
005 20231226022338.0
007 cr uuu---uuuuu
008 231226s2022 xx |||||o 00| ||eng c
024 7 |a 10.1002/adma.202202625  |2 doi 
028 5 2 |a pubmed24n1147.xml 
035 |a (DE-627)NLM34425707X 
035 |a (NLM)35906003 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Yang, Cuihong  |e verfasserin  |4 aut 
245 1 0 |a Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization 
264 1 |c 2022 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 16.09.2022 
500 |a Date Revised 16.09.2022 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2022 Wiley-VCH GmbH. 
520 |a In cancer radiotherapy, the lack of fixed DNA damage by oxygen in hypoxic microenvironment of solid tumors often leads to severe radioresistance. Nitric oxide (NO) is a potent radiosensitizer that acts in two ways. It can directly react with the radical DNA thus fixing the damage. It also normalizes the abnormal tumor vessels, thereby increasing blood perfusion and oxygen supply. To achieve these functions, the dosage and duration of NO treatment need to be carefully controlled, otherwise it will lead to the exact opposite outcomes. However, a delivery method that fulfills both requirements is still lacking. A NO depot is designed for the control of NO releasing both over quantity and duration for hypoxic tumor vessel normalization and radiosensitization. In B16-tumor-bearing mice, the depot can provide low dosage NO continuously and release large amount of NO immediately before irradiation for a short period of time. These two modes of treatment work in synergy to reverse the radioresistance of B16 tumors more efficiently than releasing at single dosage 
650 4 |a Journal Article 
650 4 |a nitric oxide 
650 4 |a radiosensitization 
650 4 |a self-assembling peptides 
650 4 |a supramolecular hydrogels 
650 4 |a vessel normalization 
650 7 |a Radiation-Sensitizing Agents  |2 NLM 
650 7 |a Nitric Oxide  |2 NLM 
650 7 |a 31C4KY9ESH  |2 NLM 
650 7 |a Oxygen  |2 NLM 
650 7 |a S88TT14065  |2 NLM 
700 1 |a Mu, Ganen  |e verfasserin  |4 aut 
700 1 |a Zhang, Ying  |e verfasserin  |4 aut 
700 1 |a Gao, Yang  |e verfasserin  |4 aut 
700 1 |a Zhang, Wenxue  |e verfasserin  |4 aut 
700 1 |a Liu, Jinjian  |e verfasserin  |4 aut 
700 1 |a Zhang, Wenwen  |e verfasserin  |4 aut 
700 1 |a Li, Paiyun  |e verfasserin  |4 aut 
700 1 |a Yang, Lijun  |e verfasserin  |4 aut 
700 1 |a Yang, Zhimou  |e verfasserin  |4 aut 
700 1 |a Gao, Jie  |e verfasserin  |4 aut 
700 1 |a Liu, Jianfeng  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 34(2022), 37 vom: 15. Sept., Seite e2202625  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:34  |g year:2022  |g number:37  |g day:15  |g month:09  |g pages:e2202625 
856 4 0 |u http://dx.doi.org/10.1002/adma.202202625  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 34  |j 2022  |e 37  |b 15  |c 09  |h e2202625