Polysaccharide/Lipid Nanoconjugates as Alternative Building Blocks for Highly Biocompatible Microcapsules

Saccharide/lipid nanoconjugates are attractive building blocks for the construction of micro- and nanosized structures because of the roles of glycolipids in human body, courtesy of their intrinsic and functional properties. Herein, nanoconjugates based on dextran and oleic acid (Dex-OA) were synthe...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1999. - 38(2022), 31 vom: 09. Aug., Seite 9556-9566
1. Verfasser: Soto-Cruz, Jackeline (VerfasserIn)
Weitere Verfasser: Mukwaya, Vincent, Naz, Mehwish, Zhang, Peipei, López-Brenes, María José, Sáenz-Arce, Giovanni, Rojas-Carrillo, Oscar, Dou, Hongjing
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Capsules Dextrans Lipids Nanoconjugates Water 059QF0KO0R
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520 |a Saccharide/lipid nanoconjugates are attractive building blocks for the construction of micro- and nanosized structures because of the roles of glycolipids in human body, courtesy of their intrinsic and functional properties. Herein, nanoconjugates based on dextran and oleic acid (Dex-OA) were synthesized via facile amide-linkage chemistry. The resultant Dex-OA micelles could self-assemble into spherical water-filled microcapsules via a water-in-oil emulsification process. By cross-linking, the microcapsules could be transferred to aqueous media, forming a stable microcapsule dispersion. According to optical and fluorescence microscopy, the microcapsules displayed a spherical morphology, and their synthesis is dependent on the concentration of Dex-OA nanoconjugates. Furthermore, the microcapsules could easily encapsulate and retain fluorescently labeled dextran. This strategy offers a robust and efficient method for the construction of microcapsules from fully natural amphiphilic building blocks with the potential for application in diverse fields such as biomedicine, protocell research, and microreactors 
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700 1 |a Mukwaya, Vincent  |e verfasserin  |4 aut 
700 1 |a Naz, Mehwish  |e verfasserin  |4 aut 
700 1 |a Zhang, Peipei  |e verfasserin  |4 aut 
700 1 |a López-Brenes, María José  |e verfasserin  |4 aut 
700 1 |a Sáenz-Arce, Giovanni  |e verfasserin  |4 aut 
700 1 |a Rojas-Carrillo, Oscar  |e verfasserin  |4 aut 
700 1 |a Dou, Hongjing  |e verfasserin  |4 aut 
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