Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis
© 2022 The Authors. Journal of Fish Diseases published by John Wiley & Sons Ltd.
| Publié dans: | Journal of fish diseases. - 1998. - 45(2022), 11 vom: 12. Nov., Seite 1645-1658 |
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| Auteur principal: | |
| Autres auteurs: | , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2022
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| Accès à la collection: | Journal of fish diseases |
| Sujets: | Journal Article Atlantic salmon RNA seq kidney malfunction nephrocalcinosis |
| Résumé: | © 2022 The Authors. Journal of Fish Diseases published by John Wiley & Sons Ltd. Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon (Salmo salar) smolts without and with severe chronic nephrocalcinosis (NC). The study revealed that numerous genes are differentially expressed in fish with NC compared with healthy salmon. The most evident changes in gene expression patterns in the NC group were a massive downregulation of metabolism and energy production, upregulation of signalling pathways important for tissue repair and function maintenance and upregulation of inflammatory responses. Overall, the extensive tissue damage and the gene regulation responses that affect salmon with severe nephrocalcinosis are highly likely to have dramatic consequences on fish survival |
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| Description: | Date Completed 14.10.2022 Date Revised 10.09.2024 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1365-2761 |
| DOI: | 10.1111/jfd.13687 |