Synergistic Poly(lactic acid) Antibacterial Surface Combining Superhydrophobicity for Antiadhesion and Chlorophyll for Photodynamic Therapy

The problem of nosocomial infections caused by bacterial growth on material surfaces is an urgent threat to public health. Although numerous materials and methods have been explored to fight against infections, the methods are complicated and the materials are slightly toxic. It is highly desirable...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 38(2022), 29 vom: 26. Juli, Seite 8987-8998
1. Verfasser: Wang, Gege (VerfasserIn)
Weitere Verfasser: Yang, Cao, Shan, Mengyao, Jia, Hanyu, Zhang, Shike, Chen, Xin, Liu, Wentao, Liu, Xuying, Chen, Jinzhou, Wang, Xianghong
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Anti-Bacterial Agents Polyesters Chlorophyll 1406-65-1 poly(lactide) 459TN2L5F5
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520 |a The problem of nosocomial infections caused by bacterial growth on material surfaces is an urgent threat to public health. Although numerous materials and methods have been explored to fight against infections, the methods are complicated and the materials are slightly toxic. It is highly desirable to develop an antibacterial strategy that kills bacteria effectively without drug resistance and cytotoxicity. Herein, we present a synergistic antibacterial polylactic acid (PLA) surface with superhydrophobic antibacterial adhesion and photodynamic bactericidal activity. Initially, the surface displayed low-adhesion superhydrophobicity and resisted most bacterial adhesion. Furthermore, completely non-toxic chlorophyll possessed excellent photodynamic bactericidal properties under non-toxic visible light, which was incorporated into micro-/nanoscale PLA surfaces. We achieved efficient antibacterial activity using completely non-toxic materials and a facile non-solvent-induced phase separation process. This non-toxic, simple, good biocompatible, and no drug-resistant strategy has great advantages in combating bacterial infections 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Anti-Bacterial Agents  |2 NLM 
650 7 |a Polyesters  |2 NLM 
650 7 |a Chlorophyll  |2 NLM 
650 7 |a 1406-65-1  |2 NLM 
650 7 |a poly(lactide)  |2 NLM 
650 7 |a 459TN2L5F5  |2 NLM 
700 1 |a Yang, Cao  |e verfasserin  |4 aut 
700 1 |a Shan, Mengyao  |e verfasserin  |4 aut 
700 1 |a Jia, Hanyu  |e verfasserin  |4 aut 
700 1 |a Zhang, Shike  |e verfasserin  |4 aut 
700 1 |a Chen, Xin  |e verfasserin  |4 aut 
700 1 |a Liu, Wentao  |e verfasserin  |4 aut 
700 1 |a Liu, Xuying  |e verfasserin  |4 aut 
700 1 |a Chen, Jinzhou  |e verfasserin  |4 aut 
700 1 |a Wang, Xianghong  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Langmuir : the ACS journal of surfaces and colloids  |d 1992  |g 38(2022), 29 vom: 26. Juli, Seite 8987-8998  |w (DE-627)NLM098181009  |x 1520-5827  |7 nnns 
773 1 8 |g volume:38  |g year:2022  |g number:29  |g day:26  |g month:07  |g pages:8987-8998 
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