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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202203820
|2 doi
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|a pubmed25n1144.xml
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|a eng
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|a Tang, Dongsheng
|e verfasserin
|4 aut
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|a Self-Sacrificially Degradable Pseudo-Semiconducting Polymer Nanoparticles that Integrate NIR-II Fluorescence Bioimaging, Photodynamic Immunotherapy, and Photo-Activated Chemotherapy
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|c 2022
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 26.08.2022
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|a Date Revised 26.08.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, their clinical application is still hampered by their poor biodegradability. Herein, a self-sacrificially biodegradable pseudo-semiconducting polymer (PSP) for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photoactivated chemotherapy (PACT) is reported. The PSP can further co-assemble with an amphiphilic polyester with pendant doxorubicin (DOX) in its side chains via reactive oxygen species (ROS)-responsive thioketal linkages (PEDOX ), which are denoted as NPPEDOX /PSP. The NP@PEDOX /PSP can accumulate at tumor sites and generate ROS for photodynamic immunotherapy as well as near-infrared-II fluorescence (NIR-II) for bioimaging upon irradition at 808 nm. The ROS could break up thioketal linkages in PEDOX , resulting in rapid doxorubicin (DOX) release for PACT. Finally, both PEDOX and PSP are degraded sacrificially by intracellular glutathione (GSH), resulting in the dissociation of NP@PEDOX /PSP. This work highlights the application of self-sacrificially degradable PSP for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and PACT in cancer therapy
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|a Journal Article
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|a NIR-II fluorescence imaging
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|a photoactivated chemotherapy
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|a photodynamic therapy
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|a pseudo-conjugated-polymers
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|a Polymers
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Doxorubicin
|2 NLM
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|a 80168379AG
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|a Glutathione
|2 NLM
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| 650 |
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7 |
|a GAN16C9B8O
|2 NLM
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| 700 |
1 |
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|a Yu, Yingjie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jinbo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Xiying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Chaoyong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiao, Haihua
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 34 vom: 12. Aug., Seite e2203820
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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|g volume:34
|g year:2022
|g number:34
|g day:12
|g month:08
|g pages:e2203820
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|u http://dx.doi.org/10.1002/adma.202203820
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