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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erac308
|2 doi
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|a pubmed24n1225.xml
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|a (DE-627)NLM343368005
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|a (NLM)35816329
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|a DE-627
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|e rakwb
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|a eng
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|a Zhou, Jing
|e verfasserin
|4 aut
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|a A Phytophthora effector promotes homodimerization of host transcription factor StKNOX3 to enhance susceptibility
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 04.11.2022
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|a Date Revised 13.12.2023
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a Oomycete pathogens secrete hundreds of cytoplasmic RxLR effectors to modulate host immunity by targeting diverse plant proteins. Revealing how effectors manipulate host proteins is pivotal to understanding infection processes and to developing new strategies to control plant disease. Here we show that the Phytophthora infestans RxLR effector Pi22798 interacts in the nucleus with a potato class II knotted-like homeobox (KNOX) transcription factor, StKNOX3. Silencing the ortholog NbKNOX3 in Nicotiana benthamiana reduces host colonization by P. infestans, whereas transient and stable overexpression of StKNOX3 enhances infection. StKNOX3 forms a homodimer which is dependent on its KNOX II domain. The KNOX II domain is also essential for Pi22798 interaction and for StKNOX3 to enhance P. infestans colonization, indicating that StKNOX3 homodimerization contributes to susceptibility. However, critically, the effector Pi22798 promotes StKNOX3 homodimerization, rather than heterodimerization to another KNOX transcription factor StKNOX7. These results demonstrate that the oomycete effector Pi22798 increases pathogenicity by promoting homodimerization specifically of StKNOX3 to enhance susceptibility
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Class II knotted-like homeobox (KNOX) transcription factor
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|a effector
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|a homodimerization
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| 650 |
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|a pathogenicity
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|a plant immunity
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| 650 |
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|a potato late blight
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| 650 |
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|a Transcription Factors
|2 NLM
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| 700 |
1 |
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|a Qi, Yetong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nie, Jiahui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a McLellan, Hazel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boevink, Petra C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Birch, Paul R J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tian, Zhendong
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 73(2022), 19 vom: 02. Nov., Seite 6902-6915
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:73
|g year:2022
|g number:19
|g day:02
|g month:11
|g pages:6902-6915
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|u http://dx.doi.org/10.1093/jxb/erac308
|3 Volltext
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