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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c00677
|2 doi
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|a pubmed24n1141.xml
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|a (DE-627)NLM342527851
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|a (NLM)35731623
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Zhao, Chengcheng
|e verfasserin
|4 aut
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|a Domination of H-Bond Interactions in the Solvent-Triggering Gelation Process
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.07.2022
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|a Date Revised 24.08.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Gels prepared with the solvent-triggering method are attractive for their easy and fast preparation; however, the role of solvents in this process remains unclear, which hinders the efficient and accurate control of desired gel properties. In this study, the role of solvents in the solvent-triggering gelation process is studied using 9-fluorenylmethoxycarbonyl (Fmoc)-protected diphenylalanine (Fmoc-FF) as the gelator. Density functional theory (DFT)-based calculations and corresponding wavefunction analyses are conducted to identify the H-bonding interaction sites between the molecules. The calculation results clearly annotate the activating role of DMF and the triggering role of H2O in the gelation process. The solvation of Fmoc-FF by DMF can activate the H-bonding sites on the peptide chain, showing a conformation reversal and higher electrostatic potentials. Then, the H-bonding between Fmoc-FF and H2O is facilitated to trigger gelation. The physical Fmoc-FF/DMF/H2O gels show easily tuned mechanical strengths (G' of 102-105 Pa), injectable potentials (general yield strain < 100%), and stable recoverability (80-98% within 100 s). The regulation of these properties depends on not only the gelator concentration but also the H-bonding interactions with solvent molecules, which have seldom been studied in detail before. By understanding the effect of solvents, low-molecular-weight gelator-based gels can be designed, prepared, and tuned efficiently for potential applications
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Gels
|2 NLM
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|a Solvents
|2 NLM
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|a diphenylalanine
|2 NLM
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|a Phenylalanine
|2 NLM
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| 650 |
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|a 47E5O17Y3R
|2 NLM
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| 700 |
1 |
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|a Wang, Yanyao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Bofang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Mingtao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Honghui
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 38(2022), 26 vom: 05. Juli, Seite 7965-7975
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:38
|g year:2022
|g number:26
|g day:05
|g month:07
|g pages:7965-7975
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|u http://dx.doi.org/10.1021/acs.langmuir.2c00677
|3 Volltext
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