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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.2c00794
|2 doi
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|a pubmed24n1141.xml
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|a (DE-627)NLM342365029
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|a (NLM)35715215
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|a DE-627
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|a eng
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| 100 |
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|a Hu, Taishun
|e verfasserin
|4 aut
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|a Multichannel Ca2+ Generator for Synergistic Tumor Therapy via Intracellular Ca2+ Overload and Chemotherapy
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 07.07.2022
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|a Date Revised 24.08.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Ca2+ overload has attracted an increasing attention due to its benefit of precise cancer therapy, but its efficacy is limited by the strong Ca2+ excretion of cancer cells. Moreover, monotherapy of Ca2+ overload usually fails to treat tumors satisfactorily. Herein, we develop a multifunctional nanosystem that could induce Ca2+ overload by multipathway and simultaneously produce chemotherapy for synergistic tumor therapy. The nanosystem (CaMSNCUR) is prepared by synthesizing a Ca-doped mesoporous silica nanoparticle (CaMSN) followed by loading the anticancer drug curcumin (CUR). CaMSN serves as the basis Ca2+ generator to induce Ca2+ overload directly in the intracellular environment by acid-triggered Ca2+ release, while CUR could not only exhibit chemotherapy but also facilitate Ca2+ release from the endoplasmic reticulum to the cytoplasm and inhibit Ca2+ efflux out of cells to further enhance Ca2+ overload. The in vitro and in vivo results show that CaMSN@CUR could exhibit a remarkable cytotoxicity against 4T1 cells and significantly inhibit tumor growth in 4T1 tumor-bearing mice via the synergy of Ca2+ overload and CUR-mediated chemotherapy. It is expected that the designed CaMSN@CUR has a great potential for effective tumor therapy
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antineoplastic Agents
|2 NLM
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|a Drug Carriers
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|a Silicon Dioxide
|2 NLM
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|a 7631-86-9
|2 NLM
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|a Curcumin
|2 NLM
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|a IT942ZTH98
|2 NLM
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| 700 |
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|a Liu, Xinli
|e verfasserin
|4 aut
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|a Gong, Xiyu
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Botao
|e verfasserin
|4 aut
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|a Tan, Songwen
|e verfasserin
|4 aut
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|a Xu, Hui
|e verfasserin
|4 aut
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| 700 |
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|a Pan, Anqiang
|e verfasserin
|4 aut
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|a Liang, Shuquan
|e verfasserin
|4 aut
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|a He, Yongju
|e verfasserin
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|a Zhou, Fangfang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 38(2022), 26 vom: 05. Juli, Seite 8012-8020
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:38
|g year:2022
|g number:26
|g day:05
|g month:07
|g pages:8012-8020
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|u http://dx.doi.org/10.1021/acs.langmuir.2c00794
|3 Volltext
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